DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt35E2

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	193/519 - (37%)
Similarity:	295/519 - (56%)	Gaps:	36/519 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGV 74
            |.|.||:..|| |.|.....||.||.....|.|....|:|:.|...||::|.:|...:...:..:
  Fly     8 LRLIVLVVALL-PVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPVANI 71

  Fly    75 HHIRVPKL-DMLMKILLDFEYDTDLTK----WTEAQFLSEYFYNCSKFVLEDPGV-QELLRNASA 133
            |.|.||:| |.:.:|:      .:||.    |.|.:::::|.....:.|||:.|| :|:|:..|.
  Fly    72 HDIPVPELFDNIEEIV------GNLTNRKGTWNEFEYINQYTLGLVEKVLENDGVRREILQPESL 130

  Fly   134 KYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGNSAPSVYEPMSALGY----TSG 194
            ::.|||::....|||||.:.:|:||::|:|:||:.|.||.||||.:|..|....:..:    |.|
  Fly   131 QFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPSFNWFDLDTYG 195

  Fly   195 LNL---IEK---WHNLIYITEERLVERFIYLPRQIDLYKQHFP--GATTSIHDLRRRFSLVLINQ 251
            ..|   :::   |.|..:..||          |...:|:::||  ....|:.::.|.|:|:|:||
  Fly   196 GRLGHFVDQSMAWINWHWRHEE----------RHEAVYRKYFPKIADKRSLSEITRNFALILVNQ 250

  Fly   252 HFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILDEA-EHGVIYFSMGLQLLDHWLPPGMRA 315
            ||||...|..||||:||.|||:|::|..|..:|:..:..| ||||||||:|..:....|....|.
  Fly   251 HFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRK 315

  Fly   316 SMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYA 380
            .:.|.||.|.|:::||.|..|:.:...||....||||:.||.||||||||||.||.|.:|.:|..
  Fly   316 ILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRG 380

  Fly   381 VPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQ 445
            ||:|.:|.|||||:|.:.::..|:...|:::::..||....|..|:...|:...|:..:.|:.||
  Fly   381 VPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQ 445

  Fly   446 PMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLV 509
            ||:.:|||||||.|:||||||.|||:|.:.:..:.|:::||:......:.....||:....||:
  Fly   446 PMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVLCAIKLL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	171/457 (37%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	179/486 (37%)
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	178/473 (38%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	155/429 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445595
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800