DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	135/566 - (23%)
Similarity:	247/566 - (43%)	Gaps:	135/566 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSGPGIAGLLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAV 65
            :|.|.|..|.:|                    |:...| |.:|.:...|..||::||::
  Rat    16 IFFGSGSGGKVL--------------------VWPVEF-SHWLNLKIILSELVKKGHEV------ 53

  Fly    66 TIMPHIEGVHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQ-FLSEY--------FYNC-SKFVLE 120
                              :::|..:.|.|:.|.|...|.: |.|.|        |.:| ::.:.|
  Rat    54 ------------------VVLKPSVSFSYEVDKTSAIEFESFPSSYSIADVEVIFMDCVNESIYE 100

  Fly   121 DPG---------VQELLRNASAKYSLIILEASHNDALY------GF---------------SQHF 155
            .|.         :|:|....|.....:..:|:.|..|.      ||               ::..
  Rat   101 LPKQSFWGYFLMLQKLFERTSDYSERLCRDAAFNKELMTKLQNSGFDVILADPFTPCGDLLAEIL 165

  Fly   156 NAPLLGVAAY--GSSWNIDFLVGNSAPSVYEPMSALGYTSGLNLIEKWHNLIYIT---------E 209
            ..||:....:  ||::. .:..|...|..|.|::....:..:..:|:..::||:.         :
  Rat   166 KIPLVYSLRFFPGSTYE-KYSGGLPMPPSYVPIAMSELSDRMTFVERVKHMIYVLCFDFWFQVFD 229

  Fly   210 ERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHL- 273
            |:         :..:||.:.. |..|::.:...:..:.||..::.:......:||...|.|:|.
  Rat   230 EK---------KWNELYTEVL-GRPTTLSETMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLHCR 284

  Fly   274 DEKPYPLDAELKKILDEAEHGVIYFSMGLQLLDHWLPPGMRASMSD--------AFAQLKQQVIW 330
            ..||.|.:.| ..:....||||:.||:|          .|..|:::        ..||:.|:|:|
  Rat   285 PAKPLPKEIE-DFVQSSGEHGVVVFSLG----------SMVGSLTEERANVIAAGLAQIPQKVLW 338

  Fly   331 KTD--YPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQF 393
            :.:  .||.:..:..::  .|.||..:|.||..:.||||.|...:.|::::.:|::.||||.||.
  Rat   339 RFEGKKPETLGSNTRLY--KWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQK 401

  Fly   394 QNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTE 458
            .|...::..|.|.:|||..:...:::.|:..:..:.|||.||..||:..||||:..:|.|::|.|
  Rat   402 DNIVHLKTKGAAVRLDFLTMSSTDLLTALRTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIE 466

  Fly   459 YILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFL 504
            :::|||||.|:|:|..::|.:||:::||:..|...:    :.|:|:
  Rat   467 FVMRHKGAKHLRVAGHDLSWVQYHSLDVIGFLLACV----VTVMFI 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	116/500 (23%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	128/528 (24%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	132/558 (24%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	81/254 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.690