DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt35D1

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	183/517 - (35%)
Similarity:	291/517 - (56%)	Gaps:	35/517 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LFGLLC--PKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVHHIR 78
            :|.|:|  |..:....|||||.....|.|....|:|::|...||::|.:|..........:|.|.
  Fly     4 IFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDIP 68

  Fly    79 VPKL----DMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLEDPGV-QELLRNASAKYSLI 138
            ||::    :.:::|.     .|..:.|..:.|::||..|.:|.||.:.|| :::|......:.|:
  Fly    69 VPEVFENFNEVLRIA-----STPRSTWQSSDFINEYVLNLTKTVLNNEGVRRDILGPQKPHFDLV 128

  Fly   139 ILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGNSAPSVY--EPMS------ALGYTSGL 195
            |::....|.|.|.:.:|:||::|:|:||:.|.||.|:||.:|..|  .|.|      |.|
  Fly   129 IMDLWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGNVSPISYLQSPSSRFYDLEAYG----- 188

  Fly   196 NLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGAT--TSIHDLRRRFSLVLINQHFTMGRV 258
               |:..:|:..|...:..::.::.:|..||.|.||...  ..:.::.|.|.|||:|||||:|..
  Fly   189 ---ERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPLSEISRNFDLVLVNQHFTLGPP 250

  Fly   259 RSNVPNIVEVAGMHLDEKPYPLDAELKKILDEA-EHGVIYFSMGLQLLDHWLPPGMRASMSDAFA 322
            |..|||:::|.|:|:|.....|.|||...:..| |.||||||:|..:....|....|..:.:.||
  Fly   251 RPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFA 315

  Fly   323 QLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIP 387
            .|.|:::||.:...:..:..|||...||||:|||.||||||||||.||||.|||:|:..|:|.:|
  Fly   316 SLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLP 380

  Fly   388 LFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDT 452
            ..:|||:|...:.::|:...|:.|.:..:|....|..|:.|.|::..||..:.|:.||||..|:|
  Fly   381 CLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMET 445

  Fly   453 AIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLATR 514
            |||||||:|.||||.||::|.:::..::|:::||    ||...:.|::::.:...|:.:..|
  Fly   446 AIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDV----FGTFLVGALVILGIVTYLLVMTLR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	165/454 (36%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	172/483 (36%)
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	172/470 (37%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	174/491 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445600
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800