DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt37A2

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	145/539 - (26%)
Similarity:	240/539 - (44%)	Gaps:	79/539 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GIAGLLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPH 70
            ||..||.|.:.....|    :..|||.||:....|..::.....:.|.:|||.:|:|:.:..:.:
  Fly     6 GIYLLLATAICVLGGC----HGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVN 66

  Fly    71 IEGVHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLS-------------------------EY 110
            .:.:..|.||                 ||| .|:|.:|                         |:
  Fly    67 HKNITVIMVP-----------------LTK-EESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEF 113

  Fly   111 FYNCSKFVLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLV 175
            .::.....|:|..|::|..|...|:.|::.....|....||::...||::.||....:..::.|:
  Fly   114 MFDKMAGALKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLI 178

  Fly   176 GNSAPSVYEPMSALGYTSGLNLIEKWHNLIYITEERL----------VERFIYLPRQIDLYKQHF 230
            ||.....|.|       |..:.:||...:.:  .:||          :..|:...|...|||:.|
  Fly   179 GNPLEIAYVP-------SISDSVEKGKGMSF--RQRLAGYSSSFFFGIFDFVTQRRSKRLYKELF 234

  Fly   231 ---PGATTSIHDLRRRFSLVLINQHF-TMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILDEA 291
               |. .....:|.:..||:....|. :.|.:|.|||..:|:.|:.:.:.|.||...:.:.|..|
  Fly   235 GDDPN-MPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNA 298

  Fly   292 EHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWK-TDYPEMVNQSRNVFARTWFPQRAI 355
            ..|.|..|:|..:....:.|.....|.:..::|||:|||| .|..:...:|.|:|...|.||..|
  Fly   299 TDGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDI 363

  Fly   356 LNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVL 420
            |.|||:||||.|||...:.|:.::..|:|.:|:|.||..|...|.|.|........:|.......
  Fly   364 LAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKE 428

  Fly   421 AIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVD 485
            ||.:::.|..|.......|..:.|:||||.::.|:||||::||.||.|::.....||.:...|:|
  Fly   429 AILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNID 493

  Fly   486 VVSVLFGRIGLSAIIVIFL 504
            :.:::       |::::.|
  Fly   494 IYALI-------AVVLVIL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	130/478 (27%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	134/506 (26%)
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	139/513 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445714
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950