DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt316A1

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001287111.1	Gene:	Ugt316A1 / 40079	FlyBaseID:	FBgn0036842	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	168/559 - (30%)
Similarity:	262/559 - (46%)	Gaps:	67/559 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQR--GHQLTLISAVTIMPHI-- 71
            :|.|.|..|||..:..| |:|.||...:.|.||.....|:.||:.  .|.:||||     ||.
  Fly     3 ILQVFLGTLLCGIVLGA-NVLTVFPSVWKSHYLFGRRLLQELVESSGNHSVTLIS-----PHAAQ 61

  Fly    72 EGVHHIRVPK-------------LDMLMKILLDFEYDTDLTKWTEAQFLSEYFYNC-------SK 116
            ||| ...:||             |||.|    .||.:.     ..||.:.|.|...       ..
  Fly    62 EGV-DAEIPKIRELRIEGLRENWLDMGM----SFEAEE-----MRAQSVMERFTRLIYAGTTNVD 116

  Fly   117 FVLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYG-SSWNIDFLVGNSAP 180
            .:|.||.|::|| .:..|:.|:|::...:|||.|.:.::..|.:.|:..| :|| ::.:.||...
  Fly   117 ILLSDPQVRKLL-TSGEKFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSW-LNNMFGNPQS 179

  Fly   181 SVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGATTSI---HDLRR 242
            |..:|.:.|.:|..:|..::..|.:..|.|||...|.:|..|..:|..||......:   .||.:
  Fly   180 SSLDPSNFLPFTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHFELLVKELPLYRDLTK 244

  Fly   243 RFSLVLINQHFTMGRVRSNVPNIVEVAGMHL----DEKPYPLDAELKKILDEAEHGVIYFSMGLQ 303
            ..||.|||.|..:...|:.:||:|||.|:||    |:.   |...|...::.|..||||||:|..
  Fly   245 NLSLALINSHPGLHYPRAYLPNMVEVGGLHLSHLNDDN---LPKHLLSFMESAPSGVIYFSLGAD 306

  Fly   304 LLDHWLPPGMRASMSDAFAQLKQ-QVIWKTDYPEMVNQS---RNVFARTWFPQRAILNHPNVKLF 364
            :....||....|.:.|.|..||: ..:.|.:..|...:.   .||....|:||:|||:||.||:|
  Fly   307 VETAQLPQEKLAIILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADWWPQQAILHHPQVKMF 371

  Fly   365 ITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNA 429
            |:..|.||:.||:....|:|.||:..:|....||:::.||:..:.:.:|..|.::..|..|..|.
  Fly   372 ISSCGQLSVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNT 436

  Fly   430 SYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRI 494
            ||......|.:|...:..:.:..|:...:.||...|||.::.....::..:...|||:.::  .:
  Fly   437 SYVEKLGQLKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVLLII--AV 499

  Fly   495 GLSAIIVI-FLGWKLVSLATRHLE-------YRLNVPMV 525
            |...|:.| ||....:...:.|.:       ||.|:.:|
  Fly   500 GFFGILTIPFLAICFILRKSYHSQAAQDQPPYRTNLKVV 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	146/474 (31%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	152/504 (30%)
Ugt316A1	NP_001287111.1	egt	1..480	CDD:223071	155/497 (31%)
Ugt316A1	NP_001287111.1	MGT	39..448	CDD:273616	134/428 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445637
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26285
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.860