DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_964005.2	Gene:	Ugt1a5 / 394433	MGIID:	3032634	Length:	529	Species:	Mus musculus

Alignment Length:	538	Identity:	142/538 - (26%)
Similarity:	238/538 - (44%)	Gaps:	83/538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GIAGLLLTVLLFGLLCP-KLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMP 69
            |:.|||       |||. ..|..|.:| ||. ..||.:|.:...:|.|..:|||..:::
Mouse     9 GLVGLL-------LLCALPWTEGEKVL-VFP-VGGSHWLSMRDVVRELHAQGHQTVVLA------ 58

  Fly    70 HIEGVHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLEDPG--------VQE 126
                      |:::|.:|....|.:......:|. |.|.|...|...|.  |.|        ..|
Mouse    59 ----------PEVNMRIKEEDFFTFKVYAVPYTR-QELEEMMENLKVFF--DTGNYMKKIFKTSE 110

  Fly   127 LLRNASAKYSLIILEASHNDALYGFSQHFN-------------------APLLGVAAYGSSWNID 172
            .|||.|...........||::|.   .|.|                   |..||:.|      :.
Mouse   111 ALRNMSTVLLKTCTNILHNESLL---HHLNSSSFDVVFTDPVFPCGALLAKYLGIPA------VF 166

  Fly   173 FL-----------VGNSAPSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPRQIDLY 226
            ||           ....:||.|.|......:..::.:::..|::|....:.:...:..|.: .|.
Mouse   167 FLRYIPCGIEYEATQCPSPSSYIPNLFTRLSDHMDFLQRVQNMLYHLVLKYICHLLITPYE-SLA 230

  Fly   227 KQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILD-E 290
            .:.|....:|: :|....|:.|....|.:...|..:||:|.:.|::...|. ||..|.:..:: .
Mouse   231 SELFQREVSSV-ELFSYASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTKK-PLSQEFEAYVNAS 293

  Fly   291 AEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAI 355
            .|||::.||:|..:.:  :|......:::|..::.|.|:|:.......|.::|.....|.||..:
Mouse   294 GEHGIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDL 356

  Fly   356 LNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVL 420
            |.||..:.||||:|...:.|.:...||::.:|||.||..|.||||..|....|:...:..|::..
Mouse   357 LGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLEN 421

  Fly   421 AIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVD 485
            |::.::.|.|||.|...||....|:|:..:|.|::|.||::|||||.|:|.|..:::..||:::|
Mouse   422 ALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLD 486

  Fly   486 VVSVLFGRIGLSAIIVIF 503
            |:..|.. |.|:.:.::|
Mouse   487 VIGFLLA-IVLTVVFIVF 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	120/477 (25%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	130/504 (26%)
Ugt1a5	NP_964005.2	UDPGT	26..520	CDD:278624	133/514 (26%)
Ugt1a5	NP_964005.2	egt	<257..501	CDD:223071	79/247 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840633
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.690