DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt49B1

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	151/497 - (30%)
Similarity:	258/497 - (51%)	Gaps:	19/497 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVHH--IRVPKLDML 85
            :|.....|||.|.:...|.:::....:|.||::||::|.|:..::.....|.::  |.:|:.|..
  Fly    21 ELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNYKEIVIPQYDFW 85

  Fly    86 MKI--------LLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLEDPGVQELL--RNASAKYSLIIL 140
            .:|        :|:.   |||..:...:.::....:.:.|.||.|.:|.::  :|...||.|::.
  Fly    86 PEIKEMTNKNTVLEM---TDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEKNKIGKYDLLLA 147

  Fly   141 EASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGNSAPSVYEPMSALGYTSGLNLIEKWHNLI 205
            |...|:........:..|.:.::.:|::.::..|.|..:|..|.|.:.:.||..:.|.|:..|:.
  Fly   148 EQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMTLWERIGNVA 212

  Fly   206 YITEERLVERFIYLPRQIDLYKQHFP---GATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVE 267
            ....|.||..|.|.|.|..:.|:||.   ....:|.:|.|..|.:|:|.:..:...|....|::.
  Fly   213 MSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASSRPMAYNMIP 277

  Fly   268 VAGMHLDEKPYPLDAELKKILDEAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKT 332
            |.|:|: :.|..|...|:|.||.|.||.||||:|.|:....|||.......:.|..|||:|:||.
  Fly   278 VGGLHI-QPPKALPEHLQKFLDGATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKF 341

  Fly   333 DYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTK 397
            :...:.|...||..::|.||..||.|||||:||.|.||....|:|:..||:|.:|::.||.||..
  Fly   342 EDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNIN 406

  Fly   398 RMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILR 462
            :.:....|..||::.:..:|:...:.:|:.|..|:.|.:..|:.|.|:|:.||||||:|..|::.
  Fly   407 QGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIE 471

  Fly   463 HKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFL 504
            |:||.|:..|...:...|:|.:|:|.:....|.|..:::|.:
  Fly   472 HRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	139/453 (31%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	146/481 (30%)
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	151/495 (31%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	146/480 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454724
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790