DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and ugt-35

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001023694.1	Gene:	ugt-35 / 3565443	WormBaseID:	WBGene00044286	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	115/542 - (21%)
Similarity:	229/542 - (42%)	Gaps:	91/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLFGLLCPKLTNAENI-LAVFSYTFG-SSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVHHI 77
            :||.|:.....|:::: ..|:...|. |.:..:......|.:.||.:|.::.:.:..: |...:
Worm     7 ILFFLISILFQNSKSVNFLVYCPLFAHSHHTFLAKIADTLSEEGHNVTFLAPIIVQKY-ENFKY- 69

  Fly    78 RVPKLDMLMKILLDFEY---DTDLTKWTEAQFLSEYFYNCSKFVLEDPGV--------------Q 125
                    :|...|..|   |.:|.|..|....:.:    ||:..|:|.|              .
Worm    70 --------LKHTTDIIYIQPDEELKKLGEIMGSAGF----SKYWTEEPSVFSMIPSIKLFQKMFH 122

  Fly   126 ELLRNASAKYSLI-ILEASHNDALYGFSQHFNA----PLLGVAAYGSSWNIDFLVGNSAPSVYEP 185
            ::..|..|..|:: .|:....||:......|||    ..||:.....::::...:..| .|:.||
Worm   123 KIYENLRADLSILDSLKDRKFDAMIYEVLAFNAIAIQQYLGIKTLYPTFSVTHGMVLS-KSIGEP 186

  Fly   186 MSALGYTSGLNLIEKWHNLIYITEERLVE---RFIYL-----PRQIDLYKQHFPGATTSIHDLRR 242
            .|....:|.|:...:..|.    :|||:.   .|||.     |:.|.....::   ...:.:...
Worm   187 ASPATLSSALSPYGEKMNF----QERLMNTVCAFIYQVFMKPPKMISYSHPYY---EIDLKEAES 244

  Fly   243 RFSLVLINQHFTMGRVRSNVPNIVEVAGMHL-----------DEKPYPLDAELKKILDEAEHGVI 296
            :.|.|.:|.:..:...|..:...|.:.|:.:           ||....|:..:|.:|
Worm   245 KASFVFLNSNPYLDFPRPMLTKTVLIGGISVNTSQIREERLSDEYHNILNIRVKTVL-------- 301

  Fly   297 YFSMGLQLLDHWLPPGMRASMSDAFAQLKQ-QVIWK--TDYPEMVNQSRNVFARTWFPQRAILNH 358
             .|.|..:|...:|...::.:.....:... ..|||  :|..:..|..:|:....|.||.|:|..
Worm   302 -ISFGSIMLSTDMPDRYKSIIVKVIEEFPNVTFIWKYESDELDFANNLKNLHFFKWIPQTALLAD 365

  Fly   359 PNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFR-DEIVLAI 422
            ..:..|||||||.|:.|..:...|.:.:|:|.||.:|.|.:.:...:..|:.::|.. :::.:::
Worm   366 SRLSAFITHAGLGSINELSYMGKPAILVPIFADQLRNAKMLVRHNGSISLEKQDLGNFEKLRVSL 430

  Fly   423 EDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHK--GADHMRIAEQE--MSLMQYYN 483
            ..::.:.|::.||..|:::.::||:|.       .|.:::|.  ||:...:...:  ...|.:::
Worm   431 AKILKDNSFQENAEILARQLNNQPISP-------RELLIKHATFGAEFGELPSLDPYSRQMSFFS 488

  Fly   484 VDVVSV-LFGRIGLSAIIVIFL 504
            ::::.: ||..:.| ||:|.||
Worm   489 LNMIDIFLFLGVFL-AILVYFL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	101/487 (21%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	109/517 (21%)
ugt-35	NP_001023694.1	Glycosyltransferase_GTB_type	2..464	CDD:299143	103/494 (21%)
ugt-35	NP_001023694.1	UDPGT	34..506	CDD:278624	106/510 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.900