DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt36E1

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	154/517 - (29%)
Similarity:	254/517 - (49%)	Gaps:	53/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVH 75
            ||:::.|       :::..||.:|.:...|.:....|.:|.|.:.||.:.:||.........|..
  Fly    13 LLSLVAF-------SDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYK 70

  Fly    76 HIRVPKLDMLMKILL-DFEYDTDLTKWTEAQFLSEY--FYNCSKFVLED-------PGVQELLRN 130
            ...:|...:...|.| |||        ....||..|  |:...|...||       ..:.|:|:|
  Fly    71 DHLLPPSTLTDTISLEDFE--------RPYSFLFHYVEFFILHKMGREDCNTTLHSRALTEILKN 127

  Fly   131 ASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYG-SSWNIDFLVGNSAPSVYEPMSAL--GYT 192
            ....|.:|:||..:.|.....:..|.||::|:::.. ..|:.:..   .||.:...:|||  |.:
  Fly   128 PPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERF---GAPLIPSYISALFQGQS 189

  Fly   193 SGLNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGR 257
            ..::...:..|.|.:....|:.:...:|....|.:|.|.....|..||.|..||:|:||||::..
  Fly   190 QEMSFAGRLGNWITVHSLNLLYKMFTVPAGNALIRQRFGPGLPSTEDLVRNTSLMLVNQHFSLSG 254

  Fly   258 VRSNVPNIVEVAGMHLDEKPYPLDAELKKILDEAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFA 322
            .:...||::||.|:|: ..|.||.::|:||||.|..|||..|.|.||....|....|..:..|..
  Fly   255 PKPLPPNVIEVGGVHI-SPPKPLPSDLQKILDNAPKGVILISWGSQLKACSLSAARRDGIVKAIG 318

  Fly   323 QLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIP 387
            :|:|:||||.:...:.|:..|:..|.|.|||.||.|||:|:|::|.||:...|:|..|||::.:|
  Fly   319 RLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVP 383

  Fly   388 LFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNA-------SYKRNARDLSQRFHDQ 445
            ::.||..|...:.:.|:|.:|:.|.|        .|:.||.|       |:|..|::::..::::
  Fly   384 IYGDQSLNIAALVQRGMALQLELKKL--------DENTVYEALTKALDPSFKARAKEVASSYNNR 440

  Fly   446 PMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAI--IVIFLG 505
            ....::|||||.|::...|||...:.:...:|...||::||.||    :.||.:  ::..||
  Fly   441 IQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSV----VALSLLLPVITLLG 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	137/458 (30%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	148/489 (30%)
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	140/473 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454622
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890