DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt307A1

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_609097.2	Gene:	Ugt307A1 / 33993	FlyBaseID:	FBgn0031887	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	143/534 - (26%)
Similarity:	238/534 - (44%)	Gaps:	92/534 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TVLLFGLLC-------PKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMP- 69
            ::|..|..|       |....:.:||.:|.....|..::.....|.|:||||.|||   ||.:|
  Fly     9 SLLWMGYTCIFLLADSPAPVESHHILGLFVNVHRSQLMVHLAVCRALLQRGHHLTL---VTTLPL 70

  Fly    70 ---HIEG-VHHIRVP---------KLDMLMKILLDF---EYDTDLTKWTEAQFLSEYFYNCSKFV 118
               .|:| |.||.:|         ..|:::::...|   |:..||
  Fly    71 EEQEIQGNVSHIYIPWQQPKEEVSSSDLILRLERMFRRLEHSGDL-------------------- 115

  Fly   119 LEDPGVQELLRN-ASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGNSAPSV 182
            |:.|..:..||| .:..|.|::|....||.|.|.:.|||.|:..|:....:..::.|:||.....
  Fly   116 LDLPEWKMFLRNQPNTPYDLLLLGYHFNDHLLGVAAHFNCPVAIVSTQQPTGFVNSLMGNPEERW 180

  Fly   183 YEPMSALG-YTSGLN--LIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGAT-TSIHDLRRR 243
            |.|....| ..||::  :...|...:.|...|::.|         :|:.|||... .|...:||.
  Fly   181 YVPQPYDGQQRSGISAWVFGMWEKFMEILARRVLAR---------IYRLHFPEPQYPSFETMRRS 236

  Fly   244 FSLVLINQH-FTMGRVRSNVPNIVEVAGM----HLDEKPYPLDAELKKILDEAEHGVIYFSMGLQ 303
            ..|.|.|.| .:.|.:...:|::|::.|:    .||:.|..:.|        ....:|.||:|.:
  Fly   237 VVLALSNHHMISEGPIAPLIPSMVDIGGIVLEQQLDKTPLEISA--------GNRSLIIFSLGTR 293

  Fly   304 LLDHWLPPGMRASMSDAFAQLKQQVIWKT-----------DYPEMVNQSRNVFARTWFPQRAILN 357
            .........:..:.:.||||.....|:.|           |||.:.       ...|:||..:..
  Fly   294 FTWRKSTKELVRTFTKAFAQFPDYDIYWTYDGPNGSAISLDYPHLK-------VAKWWPQTQMWQ 351

  Fly   358 HPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAI 422
            ...|:|||||.|..|:.|::.|.||:|.:||..||..|.:||:.......|...||...::..||
  Fly   352 SGKVRLFITHGGKGSVSEALFYGVPMLGLPLIGDQRDNLQRMQSKNWGLTLSTNNLTHWKLAKAI 416

  Fly   423 EDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVV 487
            ..::.::||.......||.:.|:|:|..|...:|.|||:|||||.::....:::::::|:::||.
  Fly   417 TRMLSDSSYGETILKASQLYRDRPVSPSDLVTYWIEYIVRHKGAKNLHNPARQLNIIEYHSIDVY 481

  Fly   488 SVLFGRIGLSAIIV 501
            .:::|.:.|:..|:
  Fly   482 FIVYGLLILTIAIL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	130/476 (27%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	136/501 (27%)
Ugt307A1	NP_609097.2	egt	13..492	CDD:223071	141/525 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445770
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.950