DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	135/536 - (25%)
Similarity:	241/536 - (44%)	Gaps:	64/536 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGV 74
            |.|.|.||  |......|..:|.|  ...||.:..:...:..|..|||::.::
  Rat    10 LPLCVCLF--LASGFAQAGRLLVV--PMDGSHWFTMQMIVEKLSHRGHEVVVV------------ 58

  Fly    75 HHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEY-FYNCSKFVLEDPGVQELLRNASAKYSLI 138
                :|::...|...|:|...|....:|.......: |:..:::..::.|:..||:::...:..:
  Rat    59 ----IPEVSWHMGKSLNFTVKTYSVSYTLEDLNYHFKFFAHNQWKTQEVGMFSLLKHSGKGFFEL 119

  Fly   139 I----------------LEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVG----------- 176
            :                |:.|..||:  |...|:...|.:|.|.|..::.|..|
  Rat   120 LFSHCRSLFKDKKLVEYLKQSSFDAV--FLDPFDVCGLILAKYFSLPSVVFSGGIFCHYLDEGAQ 182

  Fly   177 -NSAPSVYEPMSALGYTSGLNLIEK-WHNLIYITEERLVERFIYLPRQIDLYKQHFPGATTSIHD 239
             .|.|| |.|.....:|..:...|: |::|.|:.|......|.....:|.......|   .::.|
  Rat   183 CPSPPS-YVPRILSKFTDTMTFKERVWNHLSYMKERAFCPYFFKTAVEIASEVLQTP---VTMRD 243

  Fly   240 LRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILD-EAEHGVIYFSMGLQ 303
            |....|:.:....|.:...|..:||:|.:.|::..:.. ||..|.:..:: ..|||::.||:|..
  Rat   244 LFSPVSIWMFRTDFVLEFPRPVMPNMVYIGGINCHQGK-PLSKEFEAYVNASGEHGIVVFSLGSM 307

  Fly   304 LLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHA 368
            :.:  :|......:::|..::.|.|:|:.......|.::|.....|.||..:|.||..:.||||:
  Rat   308 VSE--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHS 370

  Fly   369 GLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKR 433
            |...:.|.:...||::.:|||.||..|.||||..|....|:...:..|::..|::.::.|.|||.
  Rat   371 GSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKE 435

  Fly   434 NARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSA 498
            |...||....|:|:..:|.|::|.||::|||||.|:|.|..:::..||:::||:..|...:
  Rat   436 NIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIV---- 496

  Fly   499 IIVIFLGWKLVSLATR 514
            :.|:|:.:|..:...|
  Rat   497 LTVVFIVYKSCAYGCR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	114/469 (24%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	124/498 (25%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	128/518 (25%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	78/247 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860