DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	138/520 - (26%)
Similarity:	248/520 - (47%)	Gaps:	51/520 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLT-LISAVTIM--PHIEG--- 73
            ||..|:|.....|...:.|:...: |.::.|...|..|.||||::| |:|:.:|:  |..|.
  Rat    10 LLIQLICYFRPGACGKVLVWPTEY-SHWINIKIILNELAQRGHEVTVLVSSASILIEPTKESSIN 73

  Fly    74 --VHHIRVPKLDMLMKILLDFEYDTDLTKWT---EAQFLSEYFYNCSKFVLEDPGVQELLRNASA 133
              ::.:.:.|.|      |::.:...:.:||   |...:..|:....|...|...|.|.|..|..
  Rat    74 FEIYSVPLSKSD------LEYSFAKWIDEWTRDFETLSIWTYYSKMQKVFNEYSDVVENLCKALI 132

  Fly   134 --KYSLIILEASHNDALYG---------FSQHFNAPLLGVAAYGSSWNID-FLVGNSAPSVYEPM 186
              |..:..|:.|..|.:..         .::....||:....:...:..: |..|...|..|.|:
  Rat   133 WNKSLMKKLQGSQFDVILADAVGPCGELLAELLKTPLVYSLRFCPGYRCEKFSGGLPLPPSYVPV 197

  Fly   187 SALGYTSGLNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFP---GATTSIHDLRRRFSLVL 248
            .....:..:..:|:..|::    :.|...|.:.|.:...:.|.:.   |..|::.::..:..:.|
  Rat   198 VLSELSDRMTFVERVKNML----QMLYFDFWFQPFKEKSWSQFYSDVLGRPTTLTEMMGKADIWL 258

  Fly   249 INQHFTMGRVRSNVPNIVEVAGMHLDEKP-YPLDAELKKILDEA-EHGVIYFSMGLQLLDHWLPP 311
            |...:.:......:||...|.|:|.  || .||..|:::.:..: ||||:.||:|..:.:  |..
  Rat   259 IRTFWDLEFPHPFLPNFDFVGGLHC--KPAKPLPREMEEFVQSSGEHGVVVFSLGSMVKN--LTE 319

  Fly   312 GMRASMSDAFAQLKQQVIWKTD--YPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLI 374
            .....::.|.||:.|:|:|:.|  .|:.:..:..::  .|.||..:|.||..|.|:.|.|...:.
  Rat   320 EKANVVASALAQIPQKVVWRFDGKKPDTLGSNTRLY--KWIPQNDLLGHPKTKAFVAHGGTNGIY 382

  Fly   375 ESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLS 439
            |::::.:|::.||||.||..|...|...|.|.::||..|....::.|::.::.:.|||.||..||
  Rat   383 EAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALKIVMNDPSYKENAMRLS 447

  Fly   440 QRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFL 504
            :..||||:..:|.|::|.||::|||||.|:|....::|..||:::||:..|.    |..:.|:|:
  Rat   448 RIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIGFLL----LCVVGVVFI 508

Fly 505 504
Rat 509 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	120/468 (26%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	132/496 (27%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	133/506 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760