DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_036815.1	Gene:	Ugt1a1 / 24861	RGDID:	3935	Length:	535	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	149/543 - (27%)
Similarity:	248/543 - (45%)	Gaps:	75/543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGV 74
            |||..||..:|.|..::|..:|.:  ...||.:|.:...::.|.|:||::.:|:.       |..
  Rat    12 LLLPCLLLCVLGPSASHAGKLLVI--PIDGSHWLSMLGVIQQLQQKGHEVVVIAP-------EAS 67

  Fly    75 HHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLED---------------PGV 124
            .||:......:.|..:.|:.:.....:.|   |....::...|:|..               .|.
  Rat    68 IHIKEGSFYTMRKYPVPFQNENVTAAFVE---LGRSVFDQDPFLLRVVKTYNKVKRDSSMLLSGC 129

  Fly   125 QELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLG----VAAYGSSWNIDFLVGNS------- 178
            ..||.||....|   ||.||.|||      ...|.|.    ||.|.|...:.||  |:
  Rat   130 SHLLHNAEFMAS---LEQSHFDAL------LTDPFLPCGSIVAQYLSLPAVYFL--NALPCSLDL 183

  Fly   179 ------APSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLP-----RQIDLYKQHFPG 232
                  ||..|.|.|....|..:|.:::..|:|....|..:.|.:|.|     .:| |.|:
  Rat   184 EATQCPAPLSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVYSPYGSLATEI-LQKE---- 243

  Fly   233 ATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILD-EAEHGVI 296
              .::.||....|:.|:...|.....|..:||:|.:.|::..:|. .|..|.:..:: ..|||::
  Rat   244 --VTVKDLLSPASIWLMRNDFVKDYPRPIMPNMVFIGGINCLQKK-ALSQEFEAYVNASGEHGIV 305

  Fly   297 YFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNV 361
            .||:|..:.:  :|......:::|..::.|.|:|:.......|.::|.....|.||..:|.||..
  Rat   306 VFSLGSMVSE--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKA 368

  Fly   362 KLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLV 426
            :.||||:|...:.|.:...||::.:|||.||..|.||||..|....|:...:..|::..|::.::
  Rat   369 RAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVI 433

  Fly   427 YNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLF 491
            .|.|||.|...||....|:|:..:|.|::|.||::|||||.|:|.|..:::..||:::||:..|.
  Rat   434 NNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLL 498

  Fly   492 GRIGLSAIIVIFLGWKLVSLATR 514
            ..:    :.|:|:.:|..:...|
  Rat   499 AIV----LTVVFIVYKSCAYGCR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	127/476 (27%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	138/505 (27%)
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	141/525 (27%)
Ugt1a1	NP_036815.1	egt	<263..509	CDD:223071	78/252 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760