DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_766469.1	Gene:	Ugt2b35 / 243085	MGIID:	3576100	Length:	529	Species:	Mus musculus

Alignment Length:	530	Identity:	140/530 - (26%)
Similarity:	252/530 - (47%)	Gaps:	60/530 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IAGLLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLI---SAVTIM 68
            |:.|||..:   ..|.:.|:...:| |:...| |.::.:...|..||||||::|::   :::.:.
Mouse     6 ISALLLLQM---SCCFRSTSCGKVL-VWPLEF-SHWMNLKIILDELVQRGHEVTVLRPSASIFVD 65

  Fly    69 P-HIEGVHHIRVPK------LDMLMKILLD---FEY--DTDLT-KWTEAQF--LSEYFYNCSKFV 118
            | :..|:.....|.      |:..:..|:|   ||.  ||.|: ...:..|  ||:|..:..|..
Mouse    66 PKYSPGLKFETFPTAFSKDYLETFLTKLVDEWTFEVPRDTCLSYSLLQTLFGKLSDYSLSLCKEA 130

  Fly   119 LEDPGVQELLRNASAKYSLIILEASHNDALYG--FSQHFNAPLLGVAAYGSSWNIDFLVGNSA-P 180
            :.:.  |.:.:...:|:.::||:|.   |..|  .:|....|.|....:...:.::...|... |
Mouse   131 VSNK--QLMTKFQESKFDVLILDAM---ASCGELIAQLLQIPFLYSLRFSPGYQVEKNSGGFVLP 190

  Fly   181 SVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERF---IYLPRQIDLYKQHFPGATTSIHDLRR 242
            ..|.|:...|....:...|:..|:|.:    |...|   .:..::.|.:.....|..|::.:...
Mouse   191 PSYVPVILSGLGGQMTFTERVKNMICM----LYFDFWFQTFTEKEWDQFYSETLGRPTTLIETMG 251

  Fly   243 RFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKP-YPLDAELKKILDEA-EHGVIYFSMGLQLL 305
            :..:..|..::.:......:||:..|.|:|.  || .||..|::..:..: .|||:.||:|
Mouse   252 KAEMWFIRSYWDLEFPHPTLPNVEYVGGLHC--KPAKPLPKEMEDFVQSSGVHGVVVFSLG---- 310

  Fly   306 DHWLPPGMRASMSD--------AFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVK 362
                  .|.::|::        |.||:.|:|:|:.|.....:...|.....|.||..:|.||..|
Mouse   311 ------SMVSNMTEERANAISWALAQIPQKVLWRFDGKTPASLGPNTRIYKWLPQNDLLGHPKTK 369

  Fly   363 LFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVY 427
            .|:||.|...|.|::|:.:|::.||||.:|..|...|...|.|..|:.:.:.|.:::.|:|:::.
Mouse   370 AFVTHGGANGLYEAIHHGIPMIGIPLFSEQHDNIAHMVAKGTAVALNIRTMSRSDLLNALEEVIN 434

  Fly   428 NASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFG 492
            |.|||.|...||...|||||..::..|:|.|:::|||||.|:|.....::..||:::||:..|..
Mouse   435 NPSYKENVMWLSTIHHDQPMKPLNRTIFWIEFVMRHKGAKHLRPLAHNLTWYQYHSLDVIGFLLV 499

  Fly   493 RIGLSAIIVI 502
            .:..:|::.:
Mouse   500 CVVATAVLPV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	123/472 (26%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	131/498 (26%)
Ugt2b35	NP_766469.1	egt	8..506	CDD:223071	138/523 (26%)
Ugt2b35	NP_766469.1	UDPGT	24..525	CDD:278624	134/509 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840458
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690