DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and Ugt2b36

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001025038.1	Gene:	Ugt2b36 / 231396	MGIID:	3576103	Length:	530	Species:	Mus musculus

Alignment Length:	512	Identity:	127/512 - (24%)
Similarity:	224/512 - (43%)	Gaps:	84/512 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVHHIRVPKLDMLMKILLDFE-----YDTDLT 99
            |.::.|...|..|.|:||::|::...|.:            .||......|.||     :..|:.
Mouse    34 SHWMNIKIILDELKQKGHEVTVLRPSTSI------------FLDPKKSPGLKFETFPTSFSNDVM 86

  Fly   100 KWTEAQFLSEYFY-----NCSKFVLEDPGVQELLRNASAKYS----------------LIILEAS 143
            :...|:.:..:.|     .|..:       ..||:|...:||                :..|:.|
Mouse    87 EIIFAKAVERWTYEVPRDTCLSY-------SPLLQNIFDEYSDYCLTLCKDTVSNKQLMAKLQES 144

  Fly   144 HNDALYG---------FSQHFNAPLLGVAAYGSSWNID-FLVGNSAPSVYEPMSALGYTSGLNLI 198
            ..|.:..         .::....|.|....:...:.:: :..|...|..|.|:...|.:..:...
Mouse   145 KFDVILSDAIGPCGELIAELLQIPFLYSLRFSPGYYLEKYSGGLPLPPSYVPVILSGLSGQMTFK 209

  Fly   199 EKWHNLIYITEERLVERF---IYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRS 260
            |:..|:|.:    |...|   .:..::.|.:.....|..|::.:...:..:.||..::.:.....
Mouse   210 ERVKNMICM----LYFDFWFQTFREKKWDQFYSETLGRPTTLIETMGKAEMWLIRSYWDLEFPHP 270

  Fly   261 NVPNIVEVAGMHLDEKP-YPLDAELKKILDEA-EHGVIYFSMGLQLLDHWLPPGMRASMSD---- 319
            .:||:..|.|:|.  || .||..|::..:..: ||||:.||:|          .|.::|::
Mouse   271 TLPNVYYVGGVHC--KPAKPLPKEMEDFVQSSGEHGVVVFSLG----------SMVSNMTEEKAN 323

  Fly   320 ----AFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYA 380
                |.||:.|:|:|:.|.........|.....|.||..:|.||..|.||||.|...|.|::|:.
Mouse   324 AIAWALAQIPQKVLWRFDGKTPATLGPNTRIYKWLPQNDLLGHPKTKAFITHGGANGLYEAIHHG 388

  Fly   381 VPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQ 445
            :|::.||||.:|..|...|...|.|..|:.:.:.|.:::.|:|:::.|..||.||..||...|||
Mouse   389 IPMIGIPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDLLNALEEVIDNPFYKENAMWLSTIHHDQ 453

  Fly   446 PMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVI 502
            ||..:|.|::|.|:::|||||.|:|.....::..||:::||:..|...:.....:::
Mouse   454 PMKPLDRAVFWIEFVMRHKGAKHLRPLAYNLTWYQYHSLDVIGFLLAFVTFIVALIV 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	117/473 (25%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	127/512 (25%)
Ugt2b36	NP_001025038.1	egt	8..506	CDD:223071	127/506 (25%)
Ugt2b36	NP_001025038.1	UDPGT	24..527	CDD:278624	127/512 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840457
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690