DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	515	Identity:	140/515 - (27%)
Similarity:	241/515 - (46%)	Gaps:	49/515 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEG-----VHHI---RVP 80
            :..|..|:.|....|.|...:.......|.:|||...|:.:       ||     .:|.   |.|
Mouse    17 IARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVLLLS-------EGRDIAPSNHYSLQRYP 74

  Fly    81 KL------DMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLEDPGVQELLRN-ASAKYSLI 138
            .:      |..::..:...:...||.......|..|..||...|    |.|.|::. ...|:.|:
Mouse    75 GIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMV----GNQALIQGLKKEKFDLL 135

  Fly   139 ILEASHNDALYGFSQHFNAPLLGV--AAYGSSWNIDFLVGNSAPSVYEPMSALGYTSGLNLIEKW 201
            :::.  || :.||   ..|.||||  |.:.:.......||..||..|.|......|..:|.:|:.
Mouse   136 LVDP--ND-MCGF---VIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNFLERM 194

  Fly   202 HNL-IYITEERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNI 265
            .|. :|:. .|:...|:.||:...:.:::......|::||....||.::.....:...|..:||:
Mouse   195 KNTGVYLI-SRIGVSFLVLPKYERIMQKYNLLPAKSMYDLVHGSSLWMLCTDVALEFPRPTLPNV 258

  Fly   266 VEVAGMHLDEKPYPLDAELKKILDEA-EHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVI 329
            |.|.|: |.:...||..:|::.:..| |||.:..|.|..:  .:|...:...::.|..:|.|:||
Mouse   259 VYVGGI-LTKPASPLPEDLQRWVSGAQEHGFVLVSFGAGV--KYLSEDIANKLAGALGRLPQKVI 320

  Fly   330 WKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQ 394
            |:....:..|...|.....|.||..:|.|.|::.|::|.||.|:.|::::.||::.||||.|.:.
Mouse   321 WRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYD 385

  Fly   395 NTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEY 459
            ...|::..|:...|::..:...|:..|:..::.|.||::.|:.||:...|||...::...:|.:|
Mouse   386 TMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDY 450

  Fly   460 ILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLATRHLEYR 519
            ||||.||.|:|.|..::|..||:.:|:..||.    |.|:::.|    ::|..|:.: ||
Mouse   451 ILRHDGARHLRSAVHQISFCQYFLLDIAFVLL----LGAVLLYF----ILSYVTKFI-YR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	122/457 (27%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	132/486 (27%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	139/511 (27%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840744
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790