DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and ugt-54

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_501996.2	Gene:	ugt-54 / 188885	WormBaseID:	WBGene00012013	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	137/565 - (24%)
Similarity:	234/565 - (41%)	Gaps:	97/565 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPF----LRNLVQRGHQLTLISAVTIMPHIE 72
            :..||..|:.|...|..|||...| ....|::   ||    ::.|:.|||.:.|:
Worm     1 MKTLLGFLILPGFANCLNILFYVS-VIAQSHI---PFHNTAIKVLLDRGHTVDLV---------- 51

  Fly    73 GVHHIRVPKLDMLMKILL--------DFEYDTDLTKWTEAQFLSEYF-----------------Y 112
                  :.:|:.::|:..        .|.|:........|..||:.|                 :
Worm    52 ------IAQLNEMVKLKFPNGVGKNYTFGYEDPNFYRKNAGHLSDIFVEKPIPMAEFLTFDDMTF 110

  Fly   113 NCSKFVLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDF---- 173
            |..:.|::||.:...::..:....|    :|..|.......|..    ||.:..|......
Worm   111 NLCETVVKDPNLLNYIKQGNYDIGL----SSDYDPCANILMHAG----GVPSKASMVPTPLFQPQ 167

  Fly   174 LVGNSAPSVYEPMSALG---YTSG--------LNLIEKWHNLIYITEERLVERFIYLPRQIDLYK 227
            :|....||   |.|..|   |..|        .:||...:| ||....||:|::..|  .::.:.
Worm   168 IVSAGLPS---PASVYGTVLYPKGDDSFFNRLFHLIRHTYN-IYFVAPRLMEKYNNL--LLETFG 226

  Fly   228 QHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILDEAE 292
            ..||.|    .::.|...::|:|.:..:.:.|.....|..:.||. .:|..||:.|...||..:.
Worm   227 PTFPSA----EEIERNVDIILVNSNEIIEKPRPVSHKIKYIGGMG-KKKAQPLNKEFNDILATSN 286

  Fly   293 HGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQ-QVIWK----TDYPEMVNQSRNVFARTWFPQ 352
            .||:.||.|.|:....:|..:|.:...||..... ..:||    ||..|:...|.|:....|.||
Worm   287 KGVVLFSFGTQVATSKVPIEIRKNFVTAFKHFPDFSFLWKYDNLTDDAELFADSSNIHRVEWLPQ 351

  Fly   353 RAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDE 417
            ..:|....||.||:|.||.|.:|:....:|:|.:|||.||..|........:...::...|..:.
Worm   352 TDLLGDNRVKAFISHMGLNSFLETSAAGIPVLAVPLFIDQQHNALNAVSRDIGVIVERHQLTVEN 416

  Fly   418 IVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADH-MRIAEQEMSLMQY 481
            :|.|::.|:||..|..||:.:|:..:::|..:....:.|.||..::.|... |.:...|::...|
Worm   417 LVNALQKLLYNPKYGENAKMISKMMNEKPEQSERLFVDWVEYAAKNPGLHKIMNLPGAELTPFWY 481

  Fly   482 YNVDVVSVLFGRIGLSAIIVIFLGWKLVSLATRHLEYRLNVPMVR 526
            |:|||:.::...:..|.||:    ||.:|.    ::.::::..||
Worm   482 YSVDVILIVVLSLTSSLIII----WKTLSF----IKCQISIRSVR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	117/487 (24%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	123/517 (24%)
ugt-54	NP_501996.2	UDPGT	35..507	CDD:278624	122/510 (24%)
ugt-54	NP_501996.2	egt	<218..498	CDD:223071	77/286 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810