DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and ugt-42

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_503278.2	Gene:	ugt-42 / 185168	WormBaseID:	WBGene00017959	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	549	Identity:	122/549 - (22%)
Similarity:	222/549 - (40%)	Gaps:	73/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRN-LVQRGHQLTLISAVTIMPHIEGV 74
            ||.:|:|..|...::.. |.|.| |..||.|:......|.: |.:.||.:|::| :.:......:
Worm     3 LLILLIFVFLISNISGF-NYLVV-SPAFGHSHSTFMGKLADALTEAGHNVTVLS-IIVSSKFRNI 64

  Fly    75 HHIRVPKLDMLMKILLDFEY------DTDLTK-WTEAQFLSEYFYNCSKFV-LEDPGVQ------ 125
            .:.::.|..::::...:.:.      :.|.:: ||:...|.|...:...|. :.|.|.:
Worm    65 SYTKLTKDIVVVETTNEQDQQAENMENNDFSRYWTQEGTLLETIPSYLMFTKMSDHGYETFRNHA 129

  Fly   126 ----ELLRNASAKYSLIILEASHNDALYGFSQHFNAPL-LGVAAYGSSWNIDFLVGNSAPSVYEP 185
                |.|::...:|..:..| |:........::...|: |.|.:....:.:..|:|       ||
Worm   130 LPQMEYLKSHRPRYDAVFFE-SYLHTGKAIQEYLEIPVFLPVTSLTHDYRLAELIG-------EP 186

  Fly   186 MSALGYTSGLNLIEKWHNLIYIT--------EERLVERFIYLPRQIDLYKQHF-----PGATTSI 237
            :|. .|.||           |.|        :||::....|...||.:...::     |.....:
Worm   187 VSP-SYLSG-----------YFTNFGNIMNFQERVINTLSYYLAQILISSPNWKTLQDPSKDLLV 239

  Fly   238 HDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDE---KPYPLDAELKKILDEAEHGVIYFS 299
            .....|...|.||.:..:...|..:...:|:.|:.:|.   |...:|.....||....|.|: .|
Worm   240 ESEYYRAPYVFINSNPYIDFPRPLLSKTIEIGGITVDADALKSEKVDETWNNILKRRPHNVL-IS 303

  Fly   300 MGLQLLDHWLPPGMRASMSDAFAQLKQ-QVIWKTDYPE--MVNQSRNVFARTWFPQRAILNHPNV 361
            .|.......:|...:.:|.......|. ..|||.:..|  ..|.:.|:..:.|.||.|:|....:
Worm   304 FGTMFKSIHMPDSYKNNMVKVMKSFKNVTFIWKYESEETSFANGAENIIFKKWTPQTALLADSRL 368

  Fly   362 KLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEK----LGVAR-KLDFKNLFRDEIVLA 421
            ..|.||.||.|:.|..:...|.|..|||.||.:|:|.:.:    :.::: .|:..|..|.    |
Worm   369 SAFFTHGGLGSVNELSYLGKPALLCPLFADQVRNSKMLSRHNGSIEISKFNLESYNTLRS----A 429

  Fly   422 IEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDV 486
            :..::::.||..||..|:::...||....:..:...|:..|......:....:.|....|:.:||
Worm   430 LHSILFDESYAENAEKLAKKLEFQPAKPKELFVRHAEFAARFGEQPALDCNLRTMGFATYHLLDV 494

  Fly   487 VSVLFGRIGLSAIIVIFLGWKLV-SLATR 514
            |..|...:.|..:.::.:..|:| |||.:
Worm   495 VVCLTSFVVLVILSLVVIIRKIVQSLAIK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	105/482 (22%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	107/511 (21%)
ugt-42	NP_503278.2	Glycosyltransferase_GTB_type	14..501	CDD:299143	111/514 (22%)
ugt-42	NP_503278.2	UDPGT	22..495	CDD:278624	107/499 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.900