DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and ugt-34

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_505728.2	Gene:	ugt-34 / 185120	WormBaseID:	WBGene00009255	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	123/535 - (22%)
Similarity:	215/535 - (40%)	Gaps:	87/535 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LCPKLTNAENILAVFSYTFG-SSYLLITPFLRNLVQRGHQLTLI--------SAVTIMPHIEGVH 75
            |.|:||.:.|.| ||...|. |.:..:......|.:.||.:|.:        ..|..:.|...:.
Worm    15 LLPQLTLSYNYL-VFCPLFAHSHHKFLAKIADTLTEAGHNVTFLMPIIHREYENVKYLEHTTDIV 78

  Fly    76 HIRVPKLDMLMKILLDFEYDT----DLTKWTEAQFLSEYFYNCSK---FVLEDPGVQELLRNASA 133
            :|:..|  .|.:|..:.:|.|    |....|....:..:|...:|   .:.:|..|.:.|:|  .
Worm    79 YIQPDK--ELEEIAQNADYSTFWKNDFGILTFIPAIERFFRMFTKVHDILKKDLSVLDNLKN--R 139

  Fly   134 KYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFL------VGNSAPSVYEPMSALGYT 192
            |:..:|.|:      ..|..|.....|.:.....||::..:      :|..:...:.|::...:.
Worm   140 KFDAMIFES------LAFCAHPIREYLEIKTIFPSWSMTHMTELSQAIGEPSSPTFLPITISPFG 198

  Fly   193 SGLNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGR 257
            ..:...|:..|    |........|:.|..:..:|  :|..|....::..:...:..|.:..:..
Worm   199 DKMTFKERLLN----TLADFTFTHIFQPPTLTSFK--YPHQTFDFKEILSQAPFIFFNSNPFLDF 257

  Fly   258 VRSNVPNIVEVAG-------MHLDEKPYPLDAELKKILDEAEHGVIYFSMGLQLLDHWLPPGMRA 315
            .|..:...:|:.|       |.|::.|    .|...||:..:..|: .|.|..|....:|    .
Worm   258 PRPTLTKTIEIGGISVNATLMRLEKLP----EEYNTILNLKQQNVL-ISFGSMLRSSEMP----V 313

  Fly   316 SMSDAFAQLKQQ-----VIWK--TDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSL 373
            ...|..||:.:.     .|||  .:..|......|.....|.||.|:|....:..|||||||.|:
Worm   314 EYKDTIAQVVRSFPSVTFIWKYENNNVEFAENLPNFHFFKWVPQTALLADSRLSAFITHAGLGSI 378

  Fly   374 IESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVL-AIEDLVYNASYKRNARD 437
            .|..:...|.:.:|:|.||.:|.|.:.:...:.:||.|:|.:.:::. |::.::.:.||..||..
Worm   379 NELSYIGKPAILVPIFADQLRNAKMLVRHNGSIELDKKDLGKFDVLRDAVDAILNDKSYTNNAIL 443

  Fly   438 LSQRFHDQPMSAMDTAIWWTEYILRHKGA---------DHMRIAEQEMSLMQYYNVDVVSVLFGR 493
            |||:...||.|..|..:.:.|:     ||         .|.|    :||...::.:|:  :||
Worm   444 LSQQLESQPFSPHDLLVKYAEF-----GAKFGELPSLDPHYR----KMSFFSFFMIDI--ILF-- 495

  Fly   494 IGLSAIIVIFLGWKL 508
              |:|...||:...|
Worm   496 --LTATFAIFVSISL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	105/475 (22%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	113/513 (22%)
ugt-34	NP_505728.2	UDPGT	35..518	CDD:278624	114/514 (22%)
ugt-34	NP_505728.2	Glycosyltransferase_GTB_type	<248..500	CDD:299143	72/275 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.900