DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and ugt-41

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_504818.2	Gene:	ugt-41 / 184295	WormBaseID:	WBGene00017336	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	121/564 - (21%)
Similarity:	219/564 - (38%)	Gaps:	106/564 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITP------------FLRNLVQRGHQLTLIS 63
            ||.:||.            :|:: |.|.|.:||:::|            ...:|.:.||.:|::|
Worm     3 LLIILLL------------VLSI-SNTSGFNYLVVSPAFGHSHSTFMGKLADSLTEAGHNVTVLS 54

  Fly    64 AVTIMPHIEGVHHIRVPKLDMLM--------KILLDFEYDTDLTKWTEAQFLSEYFYNCSKFV-L 119
             :.|......:.:.:..| |:::        ::..:.|.|.....||:...:.|...:...|: :
Worm    55 -IIISSKFRNISYTKSTK-DIVVVETTTEQDQLTENMENDDFARYWTQEGTMLETIPSYLMFLKM 117

  Fly   120 EDPGVQ----------ELLRNASAKYSLIILEASHNDALYGF-----SQHFNAPL-LGVAAYGSS 168
            .:.|.:          :.|:|...:|..:..|:      :.|     .::...|: |.|.:....
Worm   118 AEDGYKTFRDHALPQMDYLKNNRPQYDAVFFES------FFFMGKAIQEYLEIPVFLPVTSITHD 176

  Fly   169 WNIDFLVGNSAPSVYEPMSALGYTSGLNLIEKWHNLIYIT--------EERLVERFIYLPRQIDL 225
            :....|:|       ||:|. .|.||           |.|        :|||.....|...||.:
Worm   177 YRFAELIG-------EPVSP-SYLSG-----------YFTNFGNIMNFQERLTNTISYYLGQILI 222

  Fly   226 YKQHF-----PGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPY---PLDA 282
            ...::     |.....:.....|...|.||.:..:...|..:...:|:.|:.:|.|..   .:|.
Worm   223 AFPNWKTLQDPSKDLLVESEYHRAPYVFINSNPYIDFPRPLLSKTIEIGGITVDVKKLKSEKVDE 287

  Fly   283 ELKKILDEAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQ-QVIWKTDYPE--MVNQSRNV 344
            :...||.:..|.|: .|.|......::|...:.:|.......|. ..|||.:..|  ..|.:.|:
Worm   288 KWDNILKKRPHNVL-ISFGSMFKSIYMPDFYKENMVKVMKSFKNVSFIWKYESEETSFANGAENI 351

  Fly   345 FARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEK----LGVA 405
            ....|.||.|:|....:..|.||.||.|:.|..:...|.|..|||.||.:|:|.:.:    :.::
Worm   352 IFSKWVPQTALLADSRLSAFFTHGGLGSVNELSYLGKPALLCPLFADQIRNSKMLTRHNGSIEIS 416

  Fly   406 R-KLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHM 469
            : .|:..|..|.    |:..:::..||..||..|:::...||....:..:...|:..|.......
Worm   417 KFNLENYNTLRS----ALHSILFAESYSENAEKLAKKLEYQPTKPKELFVRHAEFAARFGEQPAQ 477

  Fly   470 RIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLAT 513
            ....:.|....||.:||::.|...:.|...:|..:..::|.|.|
Worm   478 DSNLRTMGFAAYYLLDVIAFLTSFVLLVIFVVFIMIRQIVKLLT 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	106/499 (21%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	111/528 (21%)
ugt-41	NP_504818.2	UDPGT	22..510	CDD:278624	108/519 (21%)
ugt-41	NP_504818.2	Glycosyltransferase_GTB_type	26..512	CDD:299143	108/517 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.900