DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and ugt-21

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001293944.1	Gene:	ugt-21 / 183141	WormBaseID:	WBGene00007885	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	517	Identity:	123/517 - (23%)
Similarity:	216/517 - (41%)	Gaps:	77/517 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LAVFSYTFGSSYLLITPFLRN-LVQRGHQLTLISAV--------TIMPHIEGVHHIRV-PKLDML 85
            :.::|..||.|::.:.....: |...|:.:|::..|        |.:...:....:.. |.::.|
Worm    22 ILLYSNLFGHSHVKVLAAAADILTDAGNNVTVLMPVFDNNLRNKTSLKSTKNTIFVEAGPNVEEL 86

  Fly    86 MKILLDF-----EYDT--DLTKWTEAQFLSEYF-YNCSKFVLEDPGVQELLRNASAKYSLIILEA 142
            |..:..|     :.||  .:|....||.:...| ..|:| |:.:||:.|.|:  :..|.|.|.|
Worm    87 MSDMRQFLANAWKEDTGNPITMMKAAQDMGTAFAEQCTK-VISEPGLLEKLK--AENYDLAITE- 147

  Fly   143 SHNDALYGFSQHFNAPL-LGVAAYGSSWNIDFLVGNSAPSVYEP--MSALG--YTSGLNLIEKWH 202
            ..:...|...:..|... :.:.......::..::|....|.|.|  .|..|  .|.|
Worm   148 PFDTCGYALFEAINIRAHVAILTANRFDHVTDVIGQPIASSYVPGTQSETGDRMTMG-------- 204

  Fly   203 NLIYITEERLVERFIYL----------PRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGR 257
                   |||...|.:|          .|..:..|...| .|.|...:....|.:|.||...:..
Worm   205 -------ERLGNYFQFLVGSYFFSLIGDRDFEAAKSVVP-ITRSWRAILPEASFILTNQIPLLDF 261

  Fly   258 VRSNVPNIVEVAGMHL--DEKPYPLDAELKKILDEAEHGV-IYFSMGLQLLDHWLPPGMRASMSD 319
            .......||.:.|:.:  ::|...||.:..|||...::.| |.|....:.:|  :|...:.|::|
Worm   262 PAPTFDKIVPIGGLSVKTEKKNLKLDEKWSKILGIRKNNVFISFGSNAKSVD--MPDEFKNSLAD 324

  Fly   320 AFAQLKQQV-IWK---TDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYA 380
            .|..:.... |||   |..| :||...||....|.||..:|..|.:.:|:||.||.|:.|.....
Worm   325 VFKSMPDTTFIWKYENTSDP-IVNHLDNVHLGDWLPQNELLADPRLSVFVTHGGLGSVTELAMMG 388

  Fly   381 VPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNL----FRDEIVLAIEDLVYNASYKRNARDLSQR 441
            .|.:.||||.||.:|.:.:::.|.|..::..||    |..|   .:|.::.:..|..|::.|::.
Worm   389 TPAVMIPLFADQGRNAQMLKRHGGAVVIEKNNLADTHFMKE---TLEKVIKDPKYLENSKRLAEM 450

  Fly   442 FHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIF 503
            ..:||.:..:|.|.:.|:..|......:....:..|.::|:.:|::::|       |:|.:|
Worm   451 LTNQPTNPKETLIKYVEFAARFGKLPSLDNYGRHQSYIEYFFLDIIAIL-------AVISLF 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	116/477 (24%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	121/509 (24%)
ugt-21	NP_001293944.1	UDPGT	32..526	CDD:278624	120/507 (24%)
ugt-21	NP_001293944.1	egt	<263..504	CDD:223071	68/253 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860