DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and ugt-27

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_491436.1	Gene:	ugt-27 / 182508	WormBaseID:	WBGene00015694	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	537	Identity:	124/537 - (23%)
Similarity:	220/537 - (40%)	Gaps:	89/537 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NAENILAVFSYTFGSSYLLITPFLR----NLVQRGHQLTLISAVTIMPHIE--GVH----HIRVP 80
            |:.|:| |:|..|.:|:   |.|:.    .|.:.||.:|.:..:..:...:  |||    .|.|.
Worm    17 NSINVL-VYSPAFAASH---TNFMARLADTLTEAGHNVTFLVPIVDVARTKQLGVHVTTDVIIVE 77

  Fly    81 KLDMLMKILLDFEYDTDLTKWTEAQFLS------EYFYNCSKFVLEDPGVQELLRN-------AS 132
            |.:...:..:.|: |:....|||....|      ::|::..|.     |.:.|||.       .|
Worm    78 KDEHTTQESVPFD-DSMEAYWTEETHSSNVGESFQWFFDGMKL-----GCENLLRRHEILDQLKS 136

  Fly   133 AKYSLIILEASHNDALYGFSQHFNAPL----LGVA--------------AYGSSWNIDFL---VG 176
            ..:.:.|:|                ||    ||:|              ||     .|:|   :|
Worm   137 RNFDVAIVE----------------PLSVCGLGLAKKLEIGKTILASSCAY-----YDYLFRHIG 180

  Fly   177 NSAPSVYEPMSALGYTSG--LNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGATTSIHD 239
            .  |.|:..:.:|..|:|  :...|:..| ..:.|......:.....:..:|::||........|
Worm   181 E--PDVHSYLPSLMSTTGDVMTTFERLEN-HRVAEAMATAMYKMFDSEKAIYRKHFGDEIPDWRD 242

  Fly   240 LRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDE---KPYPLDAELKKILDEAEHGVIYFSMG 301
            |....||...|.:..:...|..:...|.:.|:.:|.   |...||.|...||::....:: .|.|
Worm   243 LLPAASLYFTNSNPYLDFPRPILQKTVSIGGISVDTKKIKSQELDKEWNHILNKRNLNML-ISFG 306

  Fly   302 LQL-LDHWLPPGMRASMSDAFAQLKQQVIWK--TDYPEMVNQSRNVFARTWFPQRAILNHPNVKL 363
            ..: ..|.|....:..:....::.....|||  |:.........|::...|.||..:||...:..
Worm   307 SMIHSSHMLDDAKKNLIKVIKSEPNVTFIWKYETNDTSFAFGIDNIYFSKWVPQSKLLNDARLTA 371

  Fly   364 FITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIV-LAIEDLVY 427
            |:||.||.|..|..|:..|.:.:|:|.||::|...:::.|.|..:....|...:|| .|::.::|
Worm   372 FLTHGGLGSTNELAHFGKPAVMVPIFGDQYRNGHMLQRHGCAIIVQKTELSNWKIVSSAVKSVLY 436

  Fly   428 NASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSV-LF 491
            :.:||:||..|:....:||:...:..:.:.|::.|......|....::::.:|...:||..: ||
Worm   437 DENYKKNAAHLADLLQNQPVKPKEIVVKYVEFVARFGPFPEMDAYGRQLNFIQRNLLDVYLIELF 501

  Fly   492 GRIGLSAIIVIFLGWKL 508
            |......||...:..:|
Worm   502 GHFLFFLIIFCLIPLQL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	114/491 (23%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	117/521 (22%)
ugt-27	NP_491436.1	UDPGT	21..500	CDD:278624	116/513 (23%)
ugt-27	NP_491436.1	egt	<230..478	CDD:223071	61/248 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860