DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and ugt-50

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_741913.1	Gene:	ugt-50 / 181413	WormBaseID:	WBGene00011564	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	532	Identity:	126/532 - (23%)
Similarity:	240/532 - (45%)	Gaps:	89/532 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQR-GHQLTLI--SAVTIMPHIEG 73
            ||.||.|..   :.||..|| |:..:...|::|:.....:|:.. ||...|.  |...::.:.:|
Worm    13 LTALLHGSF---IVNAAKIL-VYCPSISKSHVLLCSKYADLLHNAGHDTVLFIPSYSKLLDNYDG 73

  Fly    74 VHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQ------------FLSEYFYN-CSKFVLEDPGVQ 125
            ..|.:|.:|..:.:     .|||.|.......            |.::::.: |:..:.:.|.:|
Worm    74 AKHAKVWRLHNVTE-----AYDTKLGTLANVMENSHIGFIDRLTFDADFWIDMCADLLGKLPEMQ 133

  Fly   126 ELLRNASAKYSLIILEASHND---ALYGFSQHFNAP---LLGVAAYGS--SWNIDF-LVGNSAPS 181
            .::   ..|:.|:|    :|:   ......:.||.|   ||...|...  :||:.. .:.:..||
Worm   134 HII---DYKFDLVI----YNEIDPCTPAIVRLFNIPKTVLLSSEAIMDKVAWNLGLPTLPSYVPS 191

  Fly   182 VYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSL 246
            |.|..:    ...::..|:..| :|...:.:|..::.....::|:::.......||.::.|..||
Worm   192 VEENPN----HDRMSFFERMSN-VYKFFQSIVVHYLQDIHVLNLFRKEVSSDFPSIAEIIRNVSL 251

  Fly   247 VLINQHFTMGRVRSNVPNIVEVAGMHL--DEK---PYPLDAELKKILDEAEHGVIYFSMGLQLLD 306
            ||:|........||.....|.|..:..  ||.   |...|...||    .:.|.::.|.|.....
Worm   252 VLVNTDEIFDLPRSYSSKFVYVGMLEAGKDENVTLPKKQDDYFKK----GKSGSVFVSFGTVTPF 312

  Fly   307 HWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQS-------------RNVFARTWFPQRAILNH 358
            ..||..::.|:.:|..:|       .||..:|..:             :||....|.||:|:|.|
Worm   313 RSLPERIQLSILNAIQKL-------PDYHFVVKTTADDESSAQFFSTVQNVDLVDWVPQKAVLRH 370

  Fly   359 PNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLG----VARKLDFKNLFRDEIV 419
            .|:|||::|.|:.|::|:::|.||::.:|:|.|||:|.:.:|:.|    |.|:...|..|.|.|.
Worm   371 ANLKLFVSHGGMNSVLETMYYGVPMVIMPVFTDQFRNGRNVERRGAGKMVLRETVVKETFFDAIH 435

  Fly   420 LAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNV 484
            ..:|:..|::|.||    :|....::|.::.:....|.:::|:::.::|..:....:|::::.::
Worm   436 SVLEEKSYSSSVKR----ISHLMKNKPFTSEERVTKWIDFVLKYETSEHFDLESNNLSIIEHNHL 496

  Fly   485 D------VVSVL 490
            |      ::|:|
Worm   497 DLFFYLCIISLL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	116/485 (24%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	116/505 (23%)
ugt-50	NP_741913.1	egt	9..475	CDD:223071	121/497 (24%)
ugt-50	NP_741913.1	UDPGT	26..520	CDD:278624	119/516 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810