DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and ugt-6

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001369960.1	Gene:	ugt-6 / 179755	WormBaseID:	WBGene00013904	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	135/569 - (23%)
Similarity:	227/569 - (39%)	Gaps:	96/569 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLTVLLFGLLCPKLTNAENI-LAVFSYTFGSSYLL---------------ITPFLRNLVQRGHQL 59
            :|.::||..:.....||.:. ..|.|..:|.|::.               :|.|...:|...|..
Worm     1 MLQIVLFLFISTLFGNAYSYKFLVISPVYGFSHMKYMAELANHLARAGNDVTYFQPFVVDEYHDH 65

  Fly    60 TLISAVTI----MPHIE-GVHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEYFY-----NC 114
            |||...:|    ..|.| |..||  |....:........|.:|.   ..|..||:|.:     .|
Worm    66 TLIKEKSIKIWNYYHDELGRQHI--PSQGCMRDAWHSSWYQSDA---GAAILLSKYLFPAFEHMC 125

  Fly   115 SKFVLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGNS- 178
            .| :.||..:...|:  |.::.:::.||.....|| .:.:...|.:          |....||.
Worm   126 RK-MFEDTELHYDLK--SRQFDVVLSEAFDFCGLY-LASYLEMPSI----------ISTFTGNRL 176

  Fly   179 ---APSVYE---------PMSALGYTSGL--NLIEKWHNL--IYITEERLVERFIYLPRQIDLYK 227
               ||.:.|         |.|..|:.|.:  .|.:.||.:  .|...:....::..:.:..:...
Worm   177 NALAPVLGEPSFLHYLPAPTSQYGHESTIFDRLNDVWHKIWSSYGFAQLFEMQYQQVSKLTNGKV 241

  Fly   228 QHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAE----LKKIL 288
            :|:...   |||:...||    |.:..:..|...:|.:|.:.|:.:|...:..:..    |:.:|
Worm   242 KHWKDI---IHDVTYHFS----NSNPYLDFVIPTIPKVVPIGGITVDHDYWSTNGNHSELLEHVL 299

  Fly   289 DEAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQ-QVIWKTDYPEMVNQSR----NVFART 348
            :..:|.| :.|.|..:....:|...:.||...|:.... ..:||.:.|......|    ||....
Worm   300 NARKHNV-FISFGSMVRSVDMPKEFKKSMMKVFSDHPNITFLWKYELPNDQEFLRILPTNVHVAK 363

  Fly   349 WFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLG---VARKLDF 410
            ||.|.|:|:...|.||:||.||.|.:|....|.|.:.||||.||..|.|.:|:.|   :..|||.
Worm   364 WFSQSALLSDQRVNLFVTHGGLGSTMELARAAKPAIVIPLFADQPGNAKMIERHGSVEIFSKLDI 428

  Fly   411 KNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQE 475
            .|  ..::...|:.::....|::||..|:.....||::..|..:...|...|.....::....::
Worm   429 PN--SKKLSSLIQKMLNTKYYQQNANRLADTLRFQPITPTDLMVKHAENAARFGKMPNLVPHAKD 491

  Fly   476 MSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLATRHLEYRLNVPM 524
            |...:|||:|::           .||..|.|.|.|:.. |:..:|.:.:
Worm   492 MGFFEYYNIDII-----------FIVFLLVWLLFSVVA-HVFSKLKLSL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	119/493 (24%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	123/521 (24%)
ugt-6	NP_001369960.1	GT1_Gtf-like	20..456	CDD:340817	112/464 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810