DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and ugt-1

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_505671.1	Gene:	ugt-1 / 179449	WormBaseID:	WBGene00007072	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	133/557 - (23%)
Similarity:	221/557 - (39%)	Gaps:	91/557 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRG-HQLTLISAVTIMPHIEG 73
            ||||.|.|   |    .:.|.|.| |..||.|::.....:.:.:..| |.:|::...    :.|.
Worm     6 LLLTSLTF---C----YSHNFLVV-SPVFGYSHMKFMNKVADTLANGDHNVTILQTY----NYEH 58

  Fly    74 VHHIRVPKLDMLMKILLDFEYDTDLTK--------------W---------TEAQFLSEYFYN-- 113
            ...||:.| :..::||   :|..|.:|              |         |.|...|...|.
Worm    59 FGKIRMAK-NTNVEIL---DYHLDESKAVSNENSASAFKYMWNTEIINNPITGAIATSTVLYGEM 119

  Fly   114 ---CSKFVLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLV 175
               |.|.:|:....:.:|   |..:...|.|......|| ...|..   |.:....||
Worm   120 KTMCEKVLLDKKLHKWIL---SKNFDGFISEPFDFCGLY-LGDHLK---LNIIPMHSS------- 170

  Fly   176 GNSAPSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVER---FIYLP----RQIDLYKQHFPGA 233
            ..|.||||    |:|..|.||.:...... :.||:.:.:|   .|.||    ....|:::.:..|
Worm   171 TKSLPSVY----AIGEPSLLNFLPSMRTK-FGTEQTVFDRIGDIIALPCLELAFSKLFEKQYKQA 230

  Fly   234 TTSIHDLRRRFSLVLINQHFTMGRVRS-------NVPNIVEVAGMHLD-EKPYPLDAELKKILDE 290
            :..::...|.:..:|....|.......       ::|..|.:.|..:| .|...|:.|..|||..
Worm   231 SQLLNGDVRHWKEILQTATFYFSNANDFIAFPTPSLPKHVHIGGFTIDPPKNLKLEEEYNKILSL 295

  Fly   291 AEHGV-IYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQV-IWKTDYPEMVNQSR---NVFARTWF 350
            .:..| |.|...:|..|  :|...:..:...|..|.... |||.:..:.....|   |...:.|.
Worm   296 RKSTVLISFGTVIQSAD--MPESFKDGIIKMFHLLPDTTFIWKYEVEDQQFIERLPNNAILKKWV 358

  Fly   351 PQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNL-F 414
            ||.|:|..|.:|||:||.||.|.:|..:...|.|.||:|.||..|.|.:.:.|.|...|..:| .
Worm   359 PQPALLADPRLKLFVTHGGLGSTLEVAYSGKPALMIPVFGDQLLNAKMLSRHGGATVFDKYDLED 423

  Fly   415 RDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLM 479
            .:::..||::::.|..:.:.:..::....:||:......:...|:..:....|.:.......:.:
Worm   424 AEKLTSAIKEIIGNEEFNKKSHHIADLLRNQPIDPKANLLKHVEFSAKFGRVDALEPYNVHYNFV 488

  Fly   480 QYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLATRHL 516
            |||.:|..:::|..:    ||:.:|...|.....:|:
Worm   489 QYYMLDAFAIIFSIL----IIIFYLAHLLFKFVYKHV 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	115/488 (24%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	119/517 (23%)
ugt-1	NP_505671.1	UDPGT	28..528	CDD:278624	120/527 (23%)
ugt-1	NP_505671.1	egt	<190..494	CDD:223071	72/306 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.900