DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and ugt-52

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_499988.1	Gene:	ugt-52 / 176904	WormBaseID:	WBGene00018931	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	546	Identity:	129/546 - (23%)
Similarity:	230/546 - (42%)	Gaps:	69/546 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSGPGIAGLLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLIT-PFLRNLVQRGHQLTLISA 64
            :|..|..:.:...|.||.|  |::....::| .:....|.|::..| ..:.:||:.||.:.||.|
Worm     7 IFFTPMTSPIRCLVFLFTL--PRVIQTLHVL-FYILLLGKSHIDFTDSLIESLVENGHTVDLIIA 68

  Fly    65 VTIMPHIEGVHHIRVPKLDML-MKILLDFEYDTDLTK--------------WTEAQFLSEYFYNC 114
                   ....|::....:|: .|....|:.::...|              |.|..:..:...:.
Worm    69 -------RMNSHVKSNGTNMVTRKYTYGFQEESPWNKAPHLLNPFKGRERTWNEHTYYMDIVTDL 126

  Fly   115 SKFVLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAP-LLGVAAYGSSWNIDFLVG-- 176
            .:..|.|.|:...:  :|.||.:.|.....|..: ...:::..| ::.|::...........|
Worm   127 CEIGLSDAGLHAFI--SSQKYDIGIATEYENCGV-ALMKYYKIPSIVSVSSLPILDRQSLAAGMP 188

  Fly   177 NS---APSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPR-QIDLYKQHFPGATTSI 237
            ||   ..:::|......|.........|.::..|...       |..: |.::.|:|. |.....
Worm   189 NSPAVTQAIFEAEDLTTYWGKFRNFLNWAHITLIINP-------YCEKHQSEVIKKHL-GENFDT 245

  Fly   238 HDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILDEAE--HGVIYFSM 300
            .:|.....|..:|.:..:...|.:...|..:.|::|.:....||.|::|::.:..  :|::.|..
Worm   246 SNLIESLDLAFVNSNELIETPRVSSHKIKYIGGINLKKSKDRLDEEVEKVITQKPIGNGIVVFCF 310

  Fly   301 GLQLLDHWLPPGMRASMSDAFAQLKQ-QVIWKTDYPEMVNQSRNVFART-------WFPQRAILN 357
            |.|:.....|..:|.:.:.||..... ..:||.   ||.:....:||.|       |.||..:||
Worm   311 GTQVPSSLFPIEVRRAFAQAFRHFPDFTFVWKY---EMQDGDEQIFANTTNLRLLKWLPQTDLLN 372

  Fly   358 HPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAI 422
            ....|.||:|.||.|.:||.:..||:|.:|||.||..|......:|....||...|....||..:
Worm   373 DARTKAFISHVGLNSYLESSYAGVPILAVPLFADQPHNAFSGMSIGTTYMLDKTRLTTPNIVKGL 437

  Fly   423 EDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILR----HKGADHMRIAEQEMSLMQYYN 483
            |.::|::||..||:.:|:..|::|.......:.|.|:..|    |:   ::.:..|.||:.:||.
Worm   438 EAVLYDSSYTLNAKRISKMLHERPNPPKKIFVEWIEFASRNPLLHR---NLNLIGQNMSVFEYYC 499

  Fly   484 VDVVSVLFGRIGLSAIIVIF---LGW 506
            :|::|  |..:.||.:|.:|   .||
Worm   500 LDIIS--FCILLLSIVISVFYLGTGW 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	108/475 (23%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	121/508 (24%)
ugt-52	NP_499988.1	UDPGT	53..537	CDD:278624	118/497 (24%)
ugt-52	NP_499988.1	Glycosyltransferase_GTB_type	<231..517	CDD:299143	83/294 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810