DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and ugt-28

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_491437.1	Gene:	ugt-28 / 172086	WormBaseID:	WBGene00015693	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	119/548 - (21%)
Similarity:	227/548 - (41%)	Gaps:	88/548 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLTVLLF-GLLCPKLTNAENILAVFSYTFGSSYLLITPFL----RNLVQRGHQLTLISAVTIMP 69
            :||..|:| ...|.  |::.||| |:|..|.:|:   :.||    ..|.:|||.:|.     :||
Worm     1 MLLKFLIFSSFFCS--TSSLNIL-VYSPAFAASH---SNFLGKLADTLTERGHNVTY-----LMP 54

  Fly    70 HIE--------GVH-----HIRVPKLDM------------LMKILLDFEYDTDLTKWTEAQFLSE 109
            .::        ||.     .|..|..:|            :|::....|.|:..::...:.|.|:
Worm    55 VVDPEKRDECIGVKLTKDLVIVEPDEEMMSFKKGSTPNGEIMELFWKSEMDSSNSRDMFSFFNSD 119

  Fly   110 YFYNCSKFVLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWN--ID 172
            ....|..|.......:::   .|..:.:.|||......| ||.:........:|:..:.::  :|
Worm   120 MKLACRNFHKRRDIFEQM---KSRNFDVAILEPVTICGL-GFVKALGIEKTILASSSTFYDAVMD 180

  Fly   173 FLVGNSAPSVYEPMSALGYTSG-LNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGATTS 236
            : :|......|.| |....|.. :.:.|::.|.:.:.|..:....:: ..::..|::.......:
Worm   181 Y-IGEPLDYSYVP-SGFSVTGDVMTMAERYENWMVVKEINIALHDMF-DGEMKSYREFLGEDLPN 242

  Fly   237 IHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLD---EKPYPLDAELKKILDEAEHGVIYF 298
            ..:|....|:..:|.:..:...|:.:...|.:.|:.::   .|...|..:.:.||::....|: .
Worm   243 WRELLSSASIFFVNANPFLDFPRAVLQKTVPIGGISINLKWIKEQKLTKDWEDILEKRTKTVL-I 306

  Fly   299 SMGLQLLDHWLPPGMRASMSDAFAQLKQQVI---WKTDYPEMVNQSRNVFARTWFPQRAILNHPN 360
            |.|..:...::|...|..:.:....:.....   :::|.....:...|:....|.||.|:||.|.
Worm   307 SFGSMVKSAYMPKIWRNGLLEVIKSMPDVTFIFKYESDEVSFADGISNIHFSKWVPQTALLNDPR 371

  Fly   361 VKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTK--------------RMEKLGVARKLDFK 411
            :..|:||.||.|.:|..:...|.:.||:|.||.:|.:              .||.:.|.||
Worm   372 LSAFVTHGGLGSTMELAYSGKPGVVIPVFADQIRNARMIARHNGVIYLHKNSMENVKVTRK---- 432

  Fly   412 NLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEM 476
                     |:.|::|:.|||:||..|:....:||.|.|:..|.:||::..|....:.....:.:
Worm   433 ---------ALTDVLYDESYKKNAEKLTDILMNQPYSPMENVIKYTEFVGEHGPFPNTDPYGRHL 488

  Fly   477 SLMQ--YYNVDVVSVLFGRIGLSAIIVI 502
            :..|  ::::..:..|| .|.:..||.|
Worm   489 NYFQKTFFDIYALFALF-YISVGTIIAI 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	106/490 (22%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	107/518 (21%)
ugt-28	NP_491437.1	UDPGT	40..536	CDD:278624	104/503 (21%)
ugt-28	NP_491437.1	egt	<193..472	CDD:223071	65/293 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860