DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	137/557 - (24%)
Similarity:	245/557 - (43%)	Gaps:	106/557 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AGLLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIE 72
            ||.|..||...:|..||.....        .||.:|.:...:.:|.:|||.:.::
  Rat    12 AGFLFLVLWGSVLGDKLLVVPQ--------DGSHWLSMKEIVEHLSERGHDIVVL---------- 58

  Fly    73 GVHHIRVPKLDMLM-------KILLDFEYDTDLTKWTEAQF--------------LSEY------ 110
                  ||::::|:       :......|:.:..:.....|              |.||
  Rat    59 ------VPEVNLLLGESKYYRRKSFPVPYNLEELRTRYRSFGNNHFAASSPLMAPLREYRNNMIV 117

  Fly   111 ----FYNCSKFVLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLL--GV--AAY-- 165
                |::|          |.||::::   :|..|..:..|||      |..|.:  ||  |.|
  Rat   118 IDMCFFSC----------QSLLKDSA---TLSFLRENQFDAL------FTDPAMPCGVILAEYLK 163

  Fly   166 --------GSSWNIDFLVGNS-APSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPR 221
                    |...:::.::|.| :|..|.|.....::..:...::..|.|....|..:...:|...
  Rat   164 LPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIANILENYLYHCLYSKY 228

  Fly   222 QI---DLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAE 283
            :|   ||.|:..  :..::|    :.||.|:...|.....|..:||::.:.|.:..:|. .|..|
  Rat   229 EILASDLLKRDV--SLPALH----QNSLWLLRYDFVFEYPRPVMPNMIFIGGTNCKKKG-NLSQE 286

  Fly   284 LKKILD-EAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFAR 347
            .:..:: ..|||::.||:|..:.:  :|......:::|..::.|.|:|:.......|.::|....
  Rat   287 FEAYVNASGEHGIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILV 349

  Fly   348 TWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKN 412
            .|.||..:|.||..:.||||:|...:.|.:...||::.:|||.||..|.||||..|....|:...
  Rat   350 KWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLE 414

  Fly   413 LFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMS 477
            :..|::..|::.::.|.|||.|...||....|:|:..:|.|::|.||::|||||.|:|.|..:::
  Rat   415 MTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLT 479

  Fly   478 LMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLATR 514
            ..||:::||:..|...:    :.|:|:.:|..:...|
  Rat   480 WYQYHSLDVIGFLLAIV----LTVVFIVYKSCAYGCR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	114/488 (23%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	127/517 (25%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	133/545 (24%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	131/543 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860