Protein Alignment Ugt303A1 and UGT2A1

DIOPT Version :9

• Sequence 1: NP_001262470.1
• Gene: Ugt303A1 / 53503
• FlyBaseID: FBgn0040252
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 129/507 - (25%)
• Similarity: 237/507 - (46%)
• Gaps: 65/507 - (12%)

  Fly    39 GSSYLLITPFLRNLVQRGHQLT-LISAVTIMPHI---EGVHHIRVP------KLDMLMKILLDFE 93
            ||.:|.|...|..|:||.|.:| |.|:.|:..:.   ..|:...:|      .:|.|::.::...
Human   240 GSHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLW 304

  Fly    94 YD---TDLTKWT---EAQFLSEYFYN-----CSKFVLEDPGVQELLRNASAKYSLIILEASHNDA 147
            .|   |.||.|.   |...|.:.|:.     |.. ||::|.:...|:...  :.:::.:..   .
Human   305 IDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDG-VLKNPKLMARLQKGG--FDVLVADPV---T 363

  Fly   148 LYG--FSQHFNAPLLGVAAYGSSWNIDFLVGN-SAPSVYEPMSALGYTSGLNLIEKWHNLI-YIT 208
            :.|  .:.....|.:....:..:..::...|. .||..|.|.:....|..:...|:..|.| |..
Human   364 ICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALSELTDQMTFGERIKNTISYSL 428

  Fly   209 EERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHL 273
            ::.:.:.:.   .:.:.|.....|..|::.:...:..:.||..::.....|..:||...|.|:|.
Human   429 QDYIFQSYW---GEWNSYYSKILGRPTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHC 490

  Fly   274 DEKP-YPLDAELKKILDEA-EHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIW--KTDY 334
              || .||..|:::.:..: ::||:.||:|..:.:  |.......::.|.||:.|:|:|  |...
Human   491 --KPAKPLPKEMEEFIQSSGKNGVVVFSLGSMVKN--LTEEKANLIASALAQIPQKVLWRYKGKK 551

  Fly   335 PEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRM 399
            |..:..:..:|  .|.||..:|.||..|.||||.|...:.|::::.||::.:|:|.||..|...|
Human   552 PATLGNNTQLF--DWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHM 614

  Fly   400 EKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHK 464
            :..|.|.:::...:...:::.|:..::...|||.||..||:..||||:..:|.|::|.|:::|||
Human   615 KAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHK 679

  Fly   465 GADHMRIAEQEMSLMQYYNVDVVSVL---------------------FGRIG 495
            ||.|:|:|..:::..||:::||:..|                     ||:||
Human   680 GAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIG 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	114/454 (25%)
		UDPGT	39..507	CDD:278624	129/507 (25%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	125/499 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150204
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.690