DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and UGT2B11

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001064.1	Gene:	UGT2B11 / 10720	HGNCID:	12545	Length:	529	Species:	Homo sapiens

Alignment Length:	548	Identity:	134/548 - (24%)
Similarity:	256/548 - (46%)	Gaps:	92/548 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLT-LISAVTIMPHIEGVHHI 77
            :||..|.|...:.:...:.|::..: |.::.:...|:.||||||::| |.|:.:|:
Human     9 LLLIHLSCYFSSGSCGKVLVWAAEY-SHWMNMKTILKELVQRGHEVTVLASSASIL--------- 63

  Fly    78 RVPKLDMLMKILLDFE-YDTDLTK-------------WTEAQ----------------FLSEYFY 112
                .|......|.|| |.|.|||             |::.:                .|.:.|.
Human    64 ----FDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELYDIFR 124

  Fly   113 NCSKFVLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVA-AYGSSWNIDFLV- 175
            |..|.|:.:..|.:.|:  .:::.::..     ||::...: ..|.||.:. .|...:...:.:
Human   125 NFCKDVVSNKKVMKKLQ--ESRFDIVFA-----DAVFPCGE-LLAALLNIRFVYSLRFTPGYTIE 181

  Fly   176 ----GNSAPSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLP--------RQIDLYKQ 228
                |...|..|.|:.....:..:..:|:..|:||:         :|..        ::.|.:..
Human   182 RHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYV---------LYFDFWFQMSDMKKWDQFYS 237

  Fly   229 HFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKP-YPLDAELKKILDEA- 291
            ...|..|::.:...:..:.|:...::.......:||:..|.|.|.  || .||..|:::.:..:
Human   238 EVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHC--KPAKPLPKEMEEFVQSSG 300

  Fly   292 EHGVIYFSMGLQLLDHWLPPGMRAS-MSDAFAQLKQQVIWKTD--YPEMVNQSRNVFARTWFPQR 353
            |:||:.||:|..:.:   ....||: ::.|.|::.|:|:|:.|  .|:.:..:..::  .|.||.
Human   301 ENGVVVFSLGSVISN---MTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLY--KWIPQN 360

  Fly   354 AILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEI 418
            .:|.||..:.||||.|...:.|::::.:|::.||||:||..|...|:..|.|.:|||..:...::
Human   361 DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTMSSTDL 425

  Fly   419 VLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYN 483
            :.|::.::.:..||.|...||:..||||:..:|.|::|.|:::.||||.|:|:|..:::..||::
Human   426 LNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAAHDLTWFQYHS 490

  Fly   484 VDVVSVLFGRIGLSAIIV----IFLGWK 507
            :||:..|...:.....|:    :|..||
Human   491 LDVIGFLLACVATVIFIITKFCLFCFWK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	115/488 (24%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	127/521 (24%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	130/533 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150500
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690