DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt2b34

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_705826.1	Gene:	Ugt2b34 / 100727	MGIID:	2140962	Length:	532	Species:	Mus musculus

Alignment Length:	557	Identity:	129/557 - (23%)
Similarity:	248/557 - (44%)	Gaps:	113/557 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AGLLLTVL----LFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIM 68
            |.|||.:|    .||      :.....:.|:...| |.:|.:...|..|:::||::.::.....:
Mouse     7 AALLLLLLQLSGFFG------SGTGGKVLVWPMEF-SHWLNLKTILDELLKKGHEVMVLRPSASL 64

  Fly    69 PHIEGVHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLEDPG---------V 124
            .:          ::|....|    |::|..|.::.::....::.:..|::.|.|.         :
Mouse    65 SY----------EVDNTSAI----EFETYPTSYSLSELEEIFWESLKKYIYELPKQSFWGYFLML 115

  Fly   125 QELLRNASAKY-------------SLIILEASHNDALYG---------FSQHFNAPLLGVAAY-- 165
            ||::. ..:||             .:..|:.|..|.:..         .::....||:....:
Mouse   116 QEMVW-VDSKYFESLCKDVVFNKELMTKLQKSRFDVILADPFIPCGDLLAEVLKIPLVYSLRFFP 179

  Fly   166 GSSWNIDFLVGNSAPSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHF 230
            ||::. .:..|...|..|.|:.....:..:..:|:..|:||:.             ..|.:.|.|
Mouse   180 GSTYE-KYSGGLPLPPSYVPVVMSELSDRMTFMERVRNVIYML-------------CFDFWFQTF 230

  Fly   231 P------------GATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHL-DEKPYPLDA 282
            .            |..|::.:...:..:.||..::.:......:||...:.|:|. ..||.|.:.
Mouse   231 NEKNWNQLYTEVLGRPTTLSETMAKADIWLIRTYWDLEFPHPVLPNFDFIGGLHCRPAKPLPKEI 295

  Fly   283 ELKKILDEAEHGVIYFSMGLQLLDHWLPPGMRASMSD--------AFAQLKQQVIWKTD--YPEM 337
            | ..:....||||:.||:|          .|..|:::        ..||:.|:|:|:.:  .||.
Mouse   296 E-DFVQSSGEHGVVVFSLG----------SMVGSITEERANVIAAGLAQIPQKVLWRFEGKKPET 349

  Fly   338 VNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKL 402
            :..:..::  .|.||..:|.|...:.||||.|...:.|::::.:|::.||||.||:.|...::..
Mouse   350 LGSNTRLY--KWIPQNDLLGHSKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQYDNIVHLKAK 412

  Fly   403 GVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGAD 467
            |.|.:|||..:...::..|::.:..:.|||.||..||:..||||:..:|.|::|.|:::|||||.
Mouse   413 GAAVRLDFLTMSSTDLHTALKTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAK 477

  Fly   468 HMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFL 504
            |:|:|..::|.:||:::||:..|...:    :.|:|:
Mouse   478 HLRVAAHDLSWVQYHSLDVLGFLLACV----LTVMFI 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	108/494 (22%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	120/522 (23%)
Ugt2b34	NP_705826.1	UDPGT	27..529	CDD:278624	122/531 (23%)
Ugt2b34	NP_705826.1	egt	<272..510	CDD:223071	79/254 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840456
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690