DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	525	Identity:	134/525 - (25%)
Similarity:	251/525 - (47%)	Gaps:	70/525 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NILAVFS----------YTFGSSYLLITPFLRNLVQRGHQLTLI--SAVTIMPHIE----GVHHI 77
            ::|.|||          ||.||.::.:...|..|:.|||.:|::  .....|...|    ...|.
Zfish     9 SLLTVFSAGQCGNILVWYTEGSHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAKESDRFSYQHF 73

  Fly    78 RVPK--------LDMLMKILLDFEYDTDLTKWTEAQFLSEYFYN------------CSKFVLEDP 122
            .|.|        .|.||:..:   ::.|.:.:.|.|.   .|:|            |.. :|:.|
Zfish    74 SVSKSAQDMQDFFDELMRFSV---FEMDNSSFLEIQM---KFFNLGSQHQDMSLSYCDG-ILKSP 131

  Fly   123 GVQELLRNASAKYSLIILEASHNDALYGFS----QHFNAPLLGVAAYGSSWNIDFLVGN-SAPSV 182
            .:.:.|:  ..|:.:::     :|.:|..|    :..|.||:....:..:...:.:.|. .||..
Zfish   132 ELMDKLK--KGKFDVVL-----SDPMYPCSDIVAEELNVPLVYTFRFSVAHAAERMCGQIPAPPS 189

  Fly   183 YEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLV 247
            |.|.:....|..::..|:..|:::...:..:.|.|:  |:.|.|...:.|.:||..::..:..:.
Zfish   190 YVPGAMSKLTDKMSFTERIFNMLFYLSQDTLSRLIW--RRFDNYYTEYFGRSTSYCEMMGKADIW 252

  Fly   248 LINQHFTMGRVRSNVPNIVEVAGMH-LDEKPYPLDAELKKILDEAEHGVIYFSMGLQLLDHWLPP 311
            ||..::.....|..|||...:.|:| ...||.|.|.| :.:....:.|::.|::| .::|. :|.
Zfish   253 LIRTYWDFEFPRPFVPNFKYIGGLHCTPAKPLPKDME-EFVQSSGDDGIVVFTLG-SMIDK-VPK 314

  Fly   312 GMRASMSDAFAQLKQQVIWK--TDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLI 374
            .|...::.|.||:.|:|:|:  .:.|:.:.::..::  .|.||..:|.||..:.||||.|...:.
Zfish   315 EMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRIY--KWIPQNDLLGHPKTRAFITHGGTNGVY 377

  Fly   375 ESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLD-FKNLFRDEIVLAIEDLVYNASYKRNARDL 438
            |::::.||::.||||.||..|...|.....|..:| .|::...|:|..:..::.:.|||.||..|
Zfish   378 EAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSMQPQELVDKLNTVINDPSYKENAMRL 442

  Fly   439 SQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIF 503
            |:..||:||..:|.:::|.|:::|:|||.|:|:....::..||:.:||    |..:.....:|::
Zfish   443 SRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDV----FAFLTTVLTLVLY 503

  Fly   504 LGWKL 508
            :.:|:
Zfish   504 ICFKM 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	122/480 (25%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	127/502 (25%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	130/514 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.860