DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and UGT2A3

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_011530549.1	Gene:	UGT2A3 / 79799	HGNCID:	28528	Length:	533	Species:	Homo sapiens

Alignment Length:	556	Identity:	153/556 - (27%)
Similarity:	255/556 - (45%)	Gaps:	85/556 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTDVS 70
            |:|.|.|   ...|:...:::.....||:.....:.:.|:..||.:||::   ..|  |...|..
Human    11 LLLQLFC---VGCGFCGKVLVWPCDMSHWLNVKVILEELIVRGHEVTVLT---HSK--PSLIDYR 67

  Fly    71 VPNVI--EVMGGDIGALWASIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFLKSNQSFDAI--- 130
            .|:.:  ||:         .:.:..|:.......:...:..||   |.:|..:|.|..|..|
Human    68 KPSALKFEVV---------HMPQDRTEENEIFVDLALNVLPGL---STWQSVIKLNDFFVEIRGT 120

  Fly   131 ---ICETF-YN--------DAHYG-------------LAEHFNAPLI---GLATGGGLTFITDMV 167
               :||:| ||        :.:|.             :||....|.:   .::.||.:......:
Human   121 LKMMCESFIYNQTLMKKLQETNYDVMLIDPVIPCGDLMAELLAVPFVLTLRISVGGNMERSCGKL 185

  Fly   168 GSPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFP---GNKRCF 229
              |||.|:||..|....|.|:..||:.|...    .||..::........::||:.   |.....
Human   186 --PAPLSYVPVPMTGLTDRMTFLERVKNSML----SVLFHFWIQDYDYHFWEEFYSKALGRPTTL 244

  Fly   230 YKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHID-----GKWNPLPEKIERFINES-EHGAI 288
            .:....|.:.||..:....||:|:.||...|||:|..     .|.|...:::|.|:..| |.|.:
Human   245 CETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCKPAKALPKINFYLQEMENFVQSSGEDGIV 309

  Fly   289 YFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPE----NVYISDWFPQTDILA 349
            .||:||..  :::...|...|..||..:.|:|||:::    ..||.    |..:.||.||.|:|.
Human   310 VFSLGSLF--QNVTEEKANIIASALAQIPQKVLWRYK----GKKPSTLGANTRLYDWIPQNDLLG 368

  Fly   350 HPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAI 414
            |||..||:|||||....|:|||..|::|:|||.||..|:||.:..|..:.::|||:.:.:..:|:
Human   369 HPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRAL 433

  Fly   415 ERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL 479
            ..:.::.||.:....:|..:.||...|::.|::|:|.|.||:||.:|:|||..|.|:|::::||:
Human   434 RTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVI 498

  Fly   480 LIIFVVMVLLLIVLPITIYKLLKKLLLKGERTQSTK 515
                   ..||..:...|:...|..|...::...|:
Human   499 -------GFLLACVATAIFLFTKCFLFSCQKFNKTR 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	147/519 (28%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	148/540 (27%)
UGT2A3	XP_011530549.1	egt	<267..498	CDD:223071	86/236 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150238
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	1	0.950	-	0	Normalized mean entropy	S5897
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.640