DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and ugt5a2

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001070191.2	Gene:	ugt5a2 / 767756	ZFINID:	ZDB-GENE-061103-373	Length:	524	Species:	Danio rerio

Alignment Length:	570	Identity:	155/570 - (27%)
Similarity:	253/570 - (44%)	Gaps:	119/570 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVV---SVFPQKKPIPGYTDVSV 71
            |||.|..|.. ..|:|:...| ||:.....|...|...||:||||   |.:..::..|.||.::|
Zfish    12 LLCVLSRSYA-GKLLVVPVEG-SHWVNMKVLIVELHSRGHSITVVRGSSSWYIEEQSPLYTSITV 74

  Fly    72 PNVIEVMGGDIGALWASIQKTYTQNLI------------------------DHYQMGFRITRGLF 112
            .|         |.......:.:..:|:                        :.::....:|..||
Zfish    75 DN---------GVFDDDFMEKFLPHLLKIQRQGKSFWNEMALADEMIHFVTETHKQSCNMTAILF 130

  Fly   113 EDSNFQDFLKSNQSFDAIICE-----------------------TFYNDAHYGLAEHFNAPLIGL 154
            |:....:.|| :.::|.::.:                       |.|.:||:.:|
Zfish   131 ENETLMNSLK-DAAYDVVLTDPAYGSGVLLAHRLGLPLVYNVRWTVYGEAHFDIA---------- 184

  Fly   155 ATGGGLTFITDMVGSPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDY---YFLPTQEK 216
                           |:|.|:||...|...|.|:..:|::|:  :.|..:...|   :..|.||.
Zfish   185 ---------------PSPLSYVPVSGLQLTDKMTFSQRVMNM--MTYIMIRYKYSKNFGSPYQEL 232

  Fly   217 LYKEFFPGNKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFIN 281
            ..|.|.|...  |:.:.::|.|.|:....:..||||..||::.:||...... .|||..:|.|:.
Zfish   233 TQKYFGPNVN--FFSLLQDADLWLMRNDFTFEFPRPTMPNVVYMGGFQCKPA-KPLPGDLEEFVQ 294

  Fly   282 ES-EHGAIYFSMG-------SNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYI 338
            .| |||.|..|:|       |.|.         .||..|...|.|:|:|::......|...|..|
Zfish   295 SSGEHGVIMMSLGTVFGQLLSELN---------DEIAAAFAQLPQKVIWRYTGPRPANLGNNTLI 350

  Fly   339 SDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFK 403
            .:|.||.|:|.|||...||.|||.....|:|||..|::|||:..||..|::.....|...:::|.
Zfish   351 VNWLPQNDLLGHPKTKLFVAHGGTNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAKGTAKIVEFA 415

  Fly   404 TLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRL 468
            ||:...|.:|::.:...|||.:.:|.:|..:.||...|::.||:|:|.|.|::||.:|::.:.|:
Zfish   416 TLDRAVFLEALKEVLHNPSYRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAPHLRAQSFRM 480

  Fly   469 NWWQYHNVDVLLIIFVVMVLLLIVLPITIYKLLKKLLLKGERTQSTKVKR 518
            :|.:|.::||:|.: ::|||:.::|.:...|.....|.:      .||||
Zfish   481 SWIEYQSIDVILTL-MLMVLVFVLLTVYTMKYFCLCLFR------KKVKR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	144/530 (27%)
ugt5a2	NP_001070191.2	UDPGT	22..524	CDD:278624	150/559 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584451
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690