DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	515	Identity:	144/515 - (27%)
Similarity:	243/515 - (47%)	Gaps:	51/515 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVV--SVFP-----QKKPI 63
            |:..|||  |...|::..:::.....||::....:.:.||...|::||:  |..|     ||:..
Zfish     7 LVCLLLC--GVDVGWSGRVLVMPGEYSHWHNMRPVIEALVDKNHSVTVLVGSSSPTVPHTQKERF 69

  Fly    64 PGY----------TDVSVPNVIEVMGGDIGA-------LWASIQKTYTQNLIDHYQMGFRITRGL 111
            ..:          .|.::.::|.:...|..|       :|..:.|        ..:.|....|||
Zfish    70 EYHVFKVNMEKEEADAAMRDMIHLFTNDTAAKYEGEFVMWKVMSK--------FVEFGDVYFRGL 126

  Fly   112 FEDSNFQDFLKSNQSFDAIICETF--YNDAHYGLAEHFNAPLIGLATGGGLTFITD-MVGS-PAP 172
            |:....:....||  :|.:..:..  ::|.   :|:..|.|.: ::......:..: :.|. |||
Zfish   127 FDVGLLKTLRDSN--YDVLFSDPMMPFSDL---MAQKLNIPQV-ISMRATFAYAAERLCGQMPAP 185

  Fly   173 ASFVPHIMLP--FNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRN 235
            .|:||.:.|.  ..|.||..||:.|:.......:........|.:..|.|.. |......:....
Zfish   186 PSYVPAVALTDHLTDRMSFMERVENMLLYIVHSIAFPLVATFTFDGYYSEIL-GKPTTMCETMGK 249

  Fly   236 ASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTK 299
            ..:.||..:....:|||..||...|||:|.... .||.:::|.|:..| :||.:.||:||.:  |
Zfish   250 VDICLIRTYWDFEYPRPFPPNFKFVGGLHCKPA-KPLSKELEEFVQSSGDHGVVVFSLGSMI--K 311

  Fly   300 DLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLS 364
            :|...:...|..|||.:.|:|:|::..........|..|.||.||.|:|.|||..||:||||...
Zfish   312 NLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNG 376

  Fly   365 TTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQG 429
            ..|:|||..|::|||:|.||..|:.|.:..|..::||..|:.:.:...|::.:.:.|||.:.:..
Zfish   377 LYEAIYHGVPMVGLPLFGDQPDNLLHIKTKGAAVVLDIHTMGSKDLVDALKAVVNNPSYKESIMR 441

  Fly   430 ISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLL 489
            :|..:.||...|::.|:||:|.|.|::||.:|:..|..|:|:|||.:||...:..:..|:
Zfish   442 LSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSITALI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	143/504 (28%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	138/499 (28%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	85/238 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585040
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690