DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt5c2

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001038851.1	Gene:	ugt5c2 / 751669	ZFINID:	ZDB-GENE-060825-206	Length:	552	Species:	Danio rerio

Alignment Length:	541	Identity:	154/541 - (28%)
Similarity:	255/541 - (47%)	Gaps:	56/541 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TFTLILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVV----SVFPQKKPI 63
            |...|.|.||..|      .::|....| ||:.....|.|.|...|||:.|:    |.| .|:..
Zfish    37 TVITIFGSLCDGG------KILVAPLEG-SHWVNMDILIKALHGQGHTVDVIRNANSWF-IKENS 93

  Fly    64 PGYTDVSVPNV---IEVMGGDI-----------GALWASIQKTYTQNLID----HYQMGFRITRG 110
            ..|..:::||.   .|....|.           |: |.||.:.|. |:.|    .::|..::...
Zfish    94 TYYDTITIPNTKGWDEEFAADFVYKMIKYEKEKGS-WLSIVRLYL-NVFDAVKKTHEMVCQLITN 156

  Fly   111 LFEDSNFQDFLKSNQSFDAIICETFYNDAHYG----LAEHFNAPLI----GLATGGGLTFITDMV 167
            :.:.......|...| :|.::     .|..:|    ||.....|::    ...||.|...|
Zfish   157 ILDSEEILKMLNEKQ-YDLML-----TDPVWGTGIILAHKLKLPMVYNVRWTTTGEGHFDI---- 211

  Fly   168 GSPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKM 232
             :|:|.|::|.......|.||.::||.|..|.....:.|.::.:...:.:..::|..... |:::
Zfish   212 -APSPMSYIPITGSGNTDRMSFFQRLKNYFFYLLLDLQLSHFNVKQYQAICDKYFTSRVN-FHEL 274

  Fly   233 RRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNL 296
            .:.|.|.|:.......||||..||:|.:||...... .|||..:|.|:..| :||.|..|:||.:
Zfish   275 LQGADLWLMRVDFVFEFPRPTMPNIIYIGGFQCPPA-KPLPHDLEDFMQSSGDHGVIVMSLGSLI 338

  Fly   297 KTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGG 361
              .:||.:...||..|...|.|:|:|::..........|..:.||.||.|:|.|||...|::|||
Zfish   339 --GNLPENVTAEIAAAFARLPQKVIWRYTGKKPSTLSNNTLMVDWMPQKDLLGHPKTKVFISHGG 401

  Fly   362 MLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKV 426
            .....|::||..||||:|.|.||:.|:...:..|...:|....|.......||:.:.:||||...
Zfish   402 TNGVLEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKLLSIADLGENTLHAAIQEVINEPSYRLN 466

  Fly   427 VQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLI 491
            :..:|..::|:...|:::||:|:|.|.||:|||:|::.:.::.|:.||:|||::.:|.|:::|..
Zfish   467 MHKLSHLHKDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVVVTLFAVVLILTY 531

  Fly   492 VLPITIYKLLKKLLLKGERTQ 512
            .:.:|:..|..|...:..:|:
Zfish   532 CIFVTVRYLCVKCCSQKRKTE 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	147/507 (29%)
ugt5c2	NP_001038851.1	UDPGT	49..551	CDD:278624	148/526 (28%)
ugt5c2	NP_001038851.1	egt	<288..528	CDD:223071	87/242 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585112
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690