DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and UGT2B7

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001065.2	Gene:	UGT2B7 / 7364	HGNCID:	12554	Length:	529	Species:	Homo sapiens

Alignment Length:	528	Identity:	162/528 - (30%)
Similarity:	266/528 - (50%)	Gaps:	67/528 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TLILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTDV 69
            ::||.:..|..:|||....:::.:|..||:.....:...|::.||.:||::           :..
Human     7 SVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLA-----------SSA 60

  Fly    70 SV---PNVIEVMGGDIGALWASIQKTYTQNLI------------DHYQMGFR-----------IT 108
            |:   ||....:..:|..  .|:.||..:|.|            |.:.:.|.           ||
Human    61 SILFDPNNSSALKIEIYP--TSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGDIT 123

  Fly   109 RGLFED--SNFQDFLKSNQS--FDAIICETFYNDAHYGLAEHFNAPLI-GLATGGGLTFITDMVG 168
            |...:|  || :.|:|..|.  ||.|..:..:..:.. |||.||.|.: .|:...|.||.....|
Human   124 RKFCKDVVSN-KKFMKKVQESRFDVIFADAIFPCSEL-LAELFNIPFVYSLSFSPGYTFEKHSGG 186

  Fly   169 SPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFP---GNKRCFY 230
            ...|.|:||.:|....|.|:..||:.|:.::.|    .|::|.....|.:.:|:.   |......
Human   187 FIFPPSYVPVVMSELTDQMTFMERVKNMIYVLY----FDFWFEIFDMKKWDQFYSEVLGRPTTLS 247

  Fly   231 KMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGS 294
            :....|.:.||....:..||.|..||:..|||:|.... .|||:::|.|:..| |:|.:.||:||
Human   248 ETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPA-KPLPKEMEDFVQSSGENGVVVFSLGS 311

  Fly   295 NLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPE----NVYISDWFPQTDILAHPKIMA 355
              ...::...:...|..||..:.|:|||:|:    .|||:    |..:..|.||.|:|.|||..|
Human   312 --MVSNMTEERANVIASALAQIPQKVLWRFD----GNKPDTLGLNTRLYKWIPQNDLLGHPKTRA 370

  Fly   356 FVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSE 420
            |:||||.....|:|||..|::|:|:|:||..|:||.:..|..:.:||.|:::.:...|::|:.::
Human   371 FITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVIND 435

  Fly   421 PSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL--LIIF 483
            |||.:.|..:|....||...|::.|::|:|.|.||:||.:|:.||..|.|:|||::||:  |::.
Human   436 PSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVC 500

  Fly   484 VVMVLLLI 491
            |..|:.::
Human   501 VATVIFIV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	159/515 (31%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	156/511 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150451
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690