Protein Alignment Ugt302K1 and UGT2B4

DIOPT Version :9

• Sequence 1: NP_001287281.1
• Gene: Ugt302K1 / 53502
• FlyBaseID: FBgn0040251
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 156/543 - (28%)
• Similarity: 257/543 - (47%)
• Gaps: 101/543 - (18%)

  Fly     6 LILGLLCSLGYSSGYNYLMVLNSAGR--------SHFNVGHALAKGLVKAGHTITVVS------- 55
            |::.|.|.  :|||        |.|:        ||:.....:...||:.||.:||::
Human    10 LLIQLSCY--FSSG--------SCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSASISF 64

  Fly    56 -----------VFPQKKPIPGYTDVSVPNVIEVMGGDIGALWASIQKT-----YTQNLIDHYQMG 104
                       |:|.......:.|: :..:::        .||.:.|.     ::|  :......
Human    65 DPNSPSTLKFEVYPVSLTKTEFEDI-IKQLVK--------RWAELPKDTFWSYFSQ--VQEIMWT 118

  Fly   105 FR-ITRGLFED--SNFQDFLKSNQS-FDAIICETFYNDAHYG--LAEHFNAPLI-------GLAT 156
            |. |.|...:|  ||.:...|..:| ||.::.:..:   .:|  |||....|.:       |.|.
Human   119 FNDILRKFCKDIVSNKKLMKKLQESRFDVVLADAVF---PFGELLAELLKIPFVYSLRFSPGYAI 180

  Fly   157 ---GGGLTFITDMVGSPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLY 218
               .|||.|         |.|:||.:|...:|.|:..||:.|:.::.|    .:::|.....|.:
Human   181 EKHSGGLLF---------PPSYVPVVMSELSDQMTFIERVKNMIYVLY----FEFWFQIFDMKKW 232

  Fly   219 KEFFP---GNKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFI 280
            .:|:.   |......:....|.:.||..:....||.|..||:..|||:|.... .|||:::|.|:
Human   233 DQFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPA-KPLPKEMEEFV 296

  Fly   281 NES-EHGAIYFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPE----NVYISD 340
            ..| |:|.:.||:||  ...:....:...|..||..:.|:|||:|:    .|||:    |..:..
Human   297 QSSGENGVVVFSLGS--MVSNTSEERANVIASALAKIPQKVLWRFD----GNKPDTLGLNTRLYK 355

  Fly   341 WFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTL 405
            |.||.|:|.|||..||:||||.....|:|||..|::|:|:|:||..|:||.:..|..:.|||.|:
Human   356 WIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTM 420

  Fly   406 NAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNW 470
            ::.:...|::.:.::|.|.:....:|..:.||...|::.|::|:|.|.||:||.:|:.||..|.|
Human   421 SSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTW 485

  Fly   471 WQYHNVDV--LLIIFVVMVLLLI 491
            :|||::||  .|:..|..|:.:|
Human   486 FQYHSLDVTGFLLACVATVIFII 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	152/530 (29%)
UGT2B4	NP_066962.2	egt	8..512	CDD:223071	156/543 (29%)
		UDPGT	24..524	CDD:278624	149/519 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150452
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690