DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_082370.2	Gene:	Ugt2a3 / 72094	MGIID:	1919344	Length:	534	Species:	Mus musculus

Alignment Length:	544	Identity:	154/544 - (28%)
Similarity:	257/544 - (47%)	Gaps:	59/544 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVS----VFPQKKPIPGYTDVSV 71
            ||..|  .|:...:::.....||:.....:.:.|...||.:||:.    :..|.|.||.:.: ::
Mouse    15 LCWAG--CGFCSKVLVWPCDMSHWLNLKTILEELGARGHEVTVLKYPSIIIDQSKRIPLHFE-NI 76

  Fly    72 PNVIEVMGGDIGALWASIQKTYTQNLIDHYQMGFRI--TRGLFEDS-NFQD-FLKSNQSFDAIIC 132
            |.:.|:             :|....|.:...:...:  ...|:|.: ..|| ||:....|::|..
Mouse    77 PLLYEI-------------ETAENRLNEIANLAVNVIPNLSLWEAAKTLQDFFLQVTGDFESICR 128

  Fly   133 ETFYN--------DAHYG-------------LAEHFNAPLIGLATGGGLTFITDMVGS-PAPASF 175
            ...||        ||.|.             :||....|.:.........::....|. |.|.|:
Mouse   129 SVLYNQKFMDKLRDAQYDVVVIDPVVPCGELVAEVLQIPFVYTLRFSMGYYMEKHCGQLPIPLSY 193

  Fly   176 VPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFP---GNKRCFYKMRRNAS 237
            ||.:|....|:|:..||:.|:.|    .:|.:|:........:.:|:.   |....|.|....|.
Mouse   194 VPVVMSELTDNMTFTERVKNMMF----SLLFEYWLQQYDFAFWDQFYSETLGRPTTFCKTVGKAD 254

  Fly   238 LVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDL 301
            :.||..:..:.||||:.||...|||:|.... .|||:::|.|:..| |||.:.||:||  ..|:|
Mouse   255 IWLIRTYWDVEFPRPYLPNFEFVGGLHCKPA-KPLPKEMEEFVQSSGEHGVVVFSLGS--MVKNL 316

  Fly   302 PPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTT 366
            ...|...|...|..:.|:|||::..........|..:.:|.||.|:|.|||..||:||||.....
Mouse   317 TEEKANLIASVLAQIPQKVLWRYSGKKPATLGSNTRLFNWIPQNDLLGHPKTKAFITHGGTNGIY 381

  Fly   367 ESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGIS 431
            |:|||..|::|:|:..||..|:||.|..|..:.:...|:.:.:...|:..:.:||||.:....:|
Mouse   382 EAIYHGVPMVGVPMLGDQPHNIAHMEAKGAALKVSISTMTSTDLLSAVRAVINEPSYKENAMRLS 446

  Fly   432 FRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMVLLLIVLPI 495
            ..:.||...|::.|::|:|.|.||:||.:|:.||..|:|:|||::||: .::..|:.|..|:...
Mouse   447 RIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLLCVVTLTFIITKF 511

  Fly   496 TIYKLLKKLLLKGERTQSTKVKRN 519
            .:: :.:||.:|..:....:.|:|
Mouse   512 CLF-VCQKLYMKESKKMGNRKKKN 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	146/503 (29%)
Ugt2a3	NP_082370.2	UDPGT	25..526	CDD:278624	148/522 (28%)
Ugt2a3	NP_082370.2	egt	<268..507	CDD:223071	89/241 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840289
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	1	0.950	-	0	Normalized mean entropy	S5897
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.640