DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and Ugt2b1

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_690024.1	Gene:	Ugt2b1 / 71773	MGIID:	1919023	Length:	529	Species:	Mus musculus

Alignment Length:	516	Identity:	146/516 - (28%)
Similarity:	242/516 - (46%)	Gaps:	79/516 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITV------VSVFPQKKPIPGYTDVSVP-- 72
            ||...|..::|:.               ||:.||.:||      :.:.|..:....:...|.|
Mouse    33 YSHWINMKIILDE---------------LVQRGHDVTVLISSASILIGPSNESSINFEIYSAPLS 82

  Fly    73 -----NVIEVMGGDIGALWASIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFLKS-------NQ 125
                 ...|...|:    |     ||....:..:....::.:   ..|.:.|.::|       |:
Mouse    83 KDDLEYAFEKWVGN----W-----TYELKKLPFWTSYSKLQK---ISSEYSDMIESFCKAVVWNK 135

  Fly   126 S---------FDAIICETFYNDAHYGLAEHFNAPLI-GLATGGGLTFITDMVGSPAPASFVPHIM 180
            |         ||.::.:........ |:|....||: .|....|........|.|.|.|:||.::
Mouse   136 SLMKKLQGSKFDVVLADALVPCGEL-LSELLKTPLVYSLRFCPGYKCEKYSGGLPLPPSYVPVVL 199

  Fly   181 LPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFP---GNKRCFYKMRRNASLVLIN 242
            ...:|||:..||:.|:    .:.:|.|::|....||.:.:|:.   |......:|...|.:.|:.
Mouse   200 SELSDHMTFAERVKNM----LQVLLFDFWFQTFNEKSWNQFYSDVLGRPTTLTEMMGKADIWLVR 260

  Fly   243 QHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDLPPSKV 306
            ....|.||.|..||...|||:|.... .|||:::|.|:..| |||.:.||:||  ..|::...|.
Mouse   261 TFWDLKFPHPFLPNFDFVGGLHCKPA-KPLPKEMEEFVQSSGEHGVVVFSLGS--MVKNIKEEKA 322

  Fly   307 QEILKALGGLKQRVLWKFELDNLPNKPE----NVYISDWFPQTDILAHPKIMAFVTHGGMLSTTE 367
            ..:..||..:.|:|||:|:    ..||:    |..:..|.||.|:|.|||..||:.|||.....|
Mouse   323 NVVASALAQIPQKVLWRFD----GKKPDTLGSNTRLYKWIPQNDLLGHPKTKAFIAHGGTNGIYE 383

  Fly   368 SIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISF 432
            :|||..|::|:|:|.||..|:.|....|..:.:||.|::..:...|::.:.::|||.:....:|.
Mouse   384 AIYHGIPIVGIPLFGDQPDNINHIVAKGAAVRVDFDTMSTTDLLTALKTVINDPSYKENAMRLSR 448

  Fly   433 RYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL--LIIFVVMVLLLI 491
            .:.||...|::.|::|:|:|.|::||.:|:.|...|.|:|||::||:  |::.||.|:.:|
Mouse   449 IHHDQPMKPLDRAVFWIEYVMRNKGAKHLRPALHDLTWFQYHSLDVIGFLLVCVVAVVFII 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	141/503 (28%)
Ugt2b1	NP_690024.1	egt	8..508	CDD:223071	145/513 (28%)
Ugt2b1	NP_690024.1	UDPGT	24..527	CDD:278624	146/516 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840490
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690