DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_038948318.1	Gene:	Ugt2a1 / 63867	RGDID:	69432	Length:	528	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	153/551 - (27%)
Similarity:	255/551 - (46%)	Gaps:	110/551 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LMVLNSAGRSHFNVGHALAKGLVKAGHTITVV----SVFPQKKP--------IP-GYTDVSVPNV 74
            :::..|.|....|: ..|.:.||:..|::||:    ::|....|        || .||...:..:
  Rat    24 VVIWPSDGSHWLNI-KILLEELVQRNHSVTVLAASETLFINSSPDAFISFEEIPVSYTRSKIDEM 87

  Fly    75 IEVMGGDIGALWASIQKTYTQNLIDH---------------------YQMGFRITRGLFEDSNFQ 118
            ||.|    .|||           :||                     |::..:|..|:.:::...
  Rat    88 IEHM----IALW-----------LDHRPTPLTMWAFYKELGKLFAAFYKINKQICDGVLKNATLM 137

  Fly   119 DFLKSNQSFDAIICE--TFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPA---------- 171
            ..|:.. .||.:|.:  |...:            |:.|..  |:.|:..:..|||
  Rat   138 ARLQKG-GFDVLISDPVTMCGE------------LVALKL--GIPFVYTLRFSPAFTVERHCGKI 187

  Fly   172 --PASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFY---- 230
              |.|:||..:....|.|:..||:.|.  :.|.  |.||        ::|.:: |....:|
  Rat   188 PTPVSYVPAALSELTDQMTFGERVKNT--ISYS--LQDY--------IFKSYW-GEWNSYYSRVL 239

  Fly   231 -------KMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGA 287
                   :....|.:.|:..:....||||:.||...|||:|.... .|||:::|.|:..| |||.
  Rat   240 GRPTTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHCKPA-KPLPKEMEEFVQTSGEHGV 303

  Fly   288 IYFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPK 352
            :.||:||  ..|:|...|...|..||..:.|:|||:::.........|..:.||.||.|:|.|||
  Rat   304 VVFSLGS--MVKNLTEEKANLIASALAQIPQKVLWRYKGKIPATLGSNTRLFDWIPQNDLLGHPK 366

  Fly   353 IMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERI 417
            ..||:||||.....|:|||..|::|:|:|:||..|:||.:..|..:.::..|:.:.:...|:..:
  Rat   367 TRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSADLLSAVRAV 431

  Fly   418 TSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLII 482
            .:||.|.:....:|..:.||...|::.|::|:|.|.||:||.:|:.||..|:|:|||::||:..:
  Rat   432 INEPFYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFL 496

  Fly   483 FVVM---VLLLIVLPITIYKLLKKLLLKGER 510
            ...|   :||:|...:.:::.:.|...|.:|
  Rat   497 LACMASAILLVIKCCLFVFQKIGKTGKKNKR 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	146/516 (28%)
Ugt2a1	XP_038948318.1	UDPGT	22..524	CDD:278624	151/546 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860