DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001034638.1	Gene:	Ugt1a5 / 574523	RGDID:	1583689	Length:	531	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	154/560 - (27%)
Similarity:	267/560 - (47%)	Gaps:	92/560 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTDVSV 71
            :|.||.:|.::.| ..::|....| ||:.....:.:.|...||...|::
  Rat    13 LLLLLYALPWAEG-GKVLVFPMEG-SHWLSMRDVVRELHARGHQAVVLA---------------- 59

  Fly    72 PNV-IEVMGGDIGALWASIQKTYTQNLIDHYQMGFR--ITRGL---FEDSNF-QDFLKSNQ---S 126
            |.| :.:...|...|     :||.   :.:.:.|||  :.|.:   ||..|: :.||::::   :
  Rat    60 PEVTVHIKEEDFFTL-----QTYP---VPYTRQGFRQQMMRNIKVVFETGNYVKTFLETSEILKN 116

  Fly   127 FDAIICETFYNDAHYG-LAEHFN-------------------APLIGLATGGGLTFI-----TDM 166
            ...::..:..|..|.| |.:|.|                   |..:|:.|...|.:|     ::.
  Rat   117 ISTVLLRSCMNLLHNGSLLQHLNSSSFDMVLTDPVIPCGAVLAKYLGIPTVFFLRYIPCGIDSEA 181

  Fly   167 VGSPAPASFVPHIMLPFNDHMSLYERLLNVAF---LGYERVLLDYYFLPTQEKLYKEFFPGNKRC 228
            ...|.|:|::|:::...:|||:..:|:.|:.:   |.|    :.::.....|.|..|.
  Rat   182 TQCPKPSSYIPNLLTMLSDHMTFLQRVKNMLYPLALKY----ICHFSFTRYESLASEL------- 235

  Fly   229 FYKMRRNASLVLINQHVSL---------SFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES- 283
               ::|..|||.:..|.|:         .:|||..|||:.:||::...| .||.::.|.::|.|
  Rat   236 ---LQREVSLVEVLSHASVWLFRGDFVFDYPRPVMPNMVFIGGINCVIK-KPLSQEFEAYVNASG 296

  Fly   284 EHGAIYFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDIL 348
            |||.:.||:||  ...::|..|..||.:|||.:.|.|||::......|..:|..:..|.||.|:|
  Rat   297 EHGIVVFSLGS--MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLL 359

  Fly   349 AHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKA 413
            .|||..||:||.|.....|.|.:..|::.:|:|.||..|....|..|.|:.|:...:.|.:...|
  Rat   360 GHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENA 424

  Fly   414 IERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDV 478
            ::.:.:..||.:.:..:|..::|:...|::.|::|||:|.||:||.:|:.||..|.|:|||::||
  Rat   425 LKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDV 489

  Fly   479 L-LIIFVVMVLLLIVLPITIYKLLKKLLLKGERTQSTKVK 517
            : .::.:|:.::.||.....|...|....||...:|.|.|
  Rat   490 IGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	144/521 (28%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	146/537 (27%)
Ugt1a5	NP_001034638.1	egt	<259..505	CDD:223071	87/248 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344049
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790