DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	531	Identity:	148/531 - (27%)
Similarity:	253/531 - (47%)	Gaps:	55/531 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TFTLILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVV---SVFPQKKPIP 64
            |...:.|.||..|      .::|:...| ||:.....|.|.|...||:|.|:   :.:..|:...
Zfish    16 TIIPLFGFLCDGG------KILVVPLEG-SHWLNMDILIKALHGKGHSIDVIRNTNSWYVKEKSD 73

  Fly    65 GYTDVSVPN------------VIEVMGGDIG-ALWASIQKTYTQNLIDHYQMG---FRITRGLFE 113
            .|..:::|.            :.:|:..:.| :.|.|..|.:..::||:|:|.   ..||..:||
Zfish    74 YYNSITIPQSKGMDEEFVDDMISKVINHERGKSSWLSTVKLFFDSVIDNYEMTKMVCDITTSIFE 138

  Fly   114 DSNFQDFLKSNQSFDAIICETFYNDAHYG----LAEHFNAPLIGLATGGGLTFITDMVG----SP 170
            .......|:..| :|.::     .|..:|    ||.....|::     ..:.:.|.:.|    :|
Zfish   139 SEEILKTLQEKQ-YDLML-----TDPVWGMGIILAHKLKLPMV-----YNVRWTTTVDGHFNIAP 192

  Fly   171 APASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFF--PGNKRCFYKMR 233
            :|.|::|.......|.||.::|:.|:.|.....:....:.||..:.:..::|  |.:   ||::.
Zfish   193 SPMSYIPITGSGNTDRMSFFQRVKNIIFYFTNDIKYSRFSLPQYQAICDKYFDPPVD---FYQLL 254

  Fly   234 RNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLK 297
            :.|.:.|:.......||||..||:|..||...... .|||..:|.|:..| :||.|..|:|:.:.
Zfish   255 QGADIWLMRVDFVFEFPRPTMPNIIYTGGFQCTPA-KPLPHDLEDFMQSSGDHGVIVMSLGTFIS 318

  Fly   298 TKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGM 362
            .  ||.....||..|...|.|:|:|::..........|..:.||.||.|:|.|||...||.|||.
Zfish   319 A--LPEDVTAEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKDLLGHPKTKVFVAHGGT 381

  Fly   363 LSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVV 427
            ....|::||..||:|:|.|.||:.|:...:..|...::....|.......||:.:.:.|||...:
Zfish   382 NGVQEALYHGVPVVGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIKEVINNPSYRLTM 446

  Fly   428 QGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDV-LLIIFVVMVLLLI 491
            |.:|..:.|:...|:::||:|:|.|.||:|||:|::.:.::.|:.||:||| :.:|.||::.:..
Zfish   447 QKLSQLHLDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVAVTLIAVVLIFIFS 511

  Fly   492 VLPITIYKLLK 502
            :..:..|..:|
Zfish   512 IFYVVRYVCIK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	143/507 (28%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	144/519 (28%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	86/242 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585113
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690