DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt1b1

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001170917.1	Gene:	ugt1b1 / 558508	ZFINID:	ZDB-GENE-080227-10	Length:	528	Species:	Danio rerio

Alignment Length:	547	Identity:	150/547 - (27%)
Similarity:	233/547 - (42%)	Gaps:	108/547 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GLLCSLGYSSGYNYLMVLNSAG---------------RSHFNVGHALAKGLVKAGHTITVVSVFP 58
            |.|..||  ||  .|::..|||               .||:.....||..|.:.||.:.|  :.|
Zfish     5 GWLWGLG--SG--LLLLWLSAGLRPVQGGRVLVMPVEGSHWLSMKVLATELARRGHDVLV--LVP 63

  Fly    59 QKKPIPGYTDVSVPNVIEVMGGDIGALWASIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFLKS 123
            :|..:...:::.......|          .|.|......:..:|.|.              |.:|
Zfish    64 EKNILIQSSELFRTETFPV----------KISKEQLSKSLKGFQQGV--------------FTRS 104

  Fly   124 NQSFDAII---------------CET-FYNDAHYGLAEHFN------------APLIGLATG--- 157
            ....|..:               ||: .||:......:..|            .|:|..|.|
Zfish   105 PALMDVFVQLERLLNFTGSQVEGCESLLYNEPLMRKLKEQNFELMLTDPFLPCGPIIATALGVPA 169

  Fly   158 ----GGLTFITDMVGS--PAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQE- 215
                .|:....|::.|  |:|.|:||......:|.|:..||:.|....|:|.||....:....|
Zfish   170 VYFLRGMPCGIDLLASQCPSPPSYVPRFHSGTSDKMNFVERIRNFFMSGFELVLCKVMYASFDEL 234

  Fly   216 --------KLYKEFFPGNKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPL 272
                    ..|||..           ...:|.|.....:..:|||..|||:.:||::.. |...:
Zfish   235 AARYLKKDVTYKEII-----------GRGALWLHRYDFTFEYPRPIMPNMVFIGGINCQ-KSAEI 287

  Fly   273 PEKIERFINES-EHGAIYFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENV 336
            ..::|.|:|.| |||.:.||:||.:.:  :|..|.....||...:.|||||::..:...|.||||
Zfish   288 SAEVEEFVNGSGEHGIVVFSLGSLVSS--MPKEKADIFFKAFSMIPQRVLWRYTGEIPDNVPENV 350

  Fly   337 YISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLD 401
            .:..|.||.|:|.|||..||:||||.....|.|....|::.||:|.||..|:......|.|::|.
Zfish   351 KLMKWLPQNDLLGHPKARAFITHGGTHGIYEGICRGVPMVMLPLFGDQADNVHRVATRGVGVILS 415

  Fly   402 FKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQ 466
            ...:.......|:..:.:..||.:.:|.:|..:.|:...|::.|::|.|.|.||:||.:|:.||.
Zfish   416 IHDITVETLLDALNSVINNSSYKQKMQKLSAIHNDRPIQPLDLAVFWTEFVMRHKGADHLRPAAH 480

  Fly   467 RLNWWQYHNVDVLLIIFVVMVLLLIVL 493
            .|||.|||::||  |.|:::::|::.|
Zfish   481 ELNWLQYHSLDV--IGFMLLIVLIVTL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	146/532 (27%)
ugt1b1	NP_001170917.1	UDPGT	29..524	CDD:278624	140/519 (27%)
ugt1b1	NP_001170917.1	egt	<267..507	CDD:223071	89/244 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830