DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and UGT1A1

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_000454.1	Gene:	UGT1A1 / 54658	HGNCID:	12530	Length:	533	Species:	Homo sapiens

Alignment Length:	545	Identity:	151/545 - (27%)
Similarity:	252/545 - (46%)	Gaps:	57/545 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILG-LLCSLGYSSGYNYLMVLNSAGR--------SHFNVGHALAKGLVKAGHTITVVS------ 55
            |:|| |||.||        .|::.||:        ||:.......:.|.:.||.|.|::
Human    11 LVLGLLLCVLG--------PVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLY 67

  Fly    56 ----VFPQKKPIPGYTDVSVPNVIEVMGGDIGALWASI------QKTYTQNLIDHYQM----GFR 106
                .|...|..|      ||...|    |:...:.|:      ..::.|.:|..|:.    ...
Human    68 IRDGAFYTLKTYP------VPFQRE----DVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAM 122

  Fly   107 ITRGLFEDSNFQDFLKS--NQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGS 169
            :..|.....:.::.:.|  ..|||.::.:.|...:.. :|::.:.|.:........:...:....
Human   123 LLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPI-VAQYLSLPTVFFLHALPCSLEFEATQC 186

  Fly   170 PAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRR 234
            |.|.|:||..:...:|||:..:|:.|:.....:..|.|..:.| ...|..||.. .:.....:..
Human   187 PNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSP-YATLASEFLQ-REVTVQDLLS 249

  Fly   235 NASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKT 298
            :||:.|........:|||..|||:.|||::...: |||.::.|.:||.| |||.:.||:||  ..
Human   250 SASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQ-NPLSQEFEAYINASGEHGIVVFSLGS--MV 311

  Fly   299 KDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGML 363
            .::|..|...|..|||.:.|.|||::......|...|..:..|.||.|:|.||...||:||.|..
Human   312 SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSH 376

  Fly   364 STTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQ 428
            ...|||.:..|::.:|:|.||..|....|..|.|:.|:...:.:.:...|::.:.::.||.:.:.
Human   377 GVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIM 441

  Fly   429 GISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMVLLLIV 492
            .:|..::|:...|::.|::|||.|.||:||.:|:.||..|.|:|||::||: .::.||:.:..|.
Human   442 RLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT 506

  Fly   493 LPITIYKLLKKLLLKGERTQSTKVK 517
            .....|...|.|..||...::.|.|
Human   507 FKCCAYGYRKCLGKKGRVKKAHKSK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	141/506 (28%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	139/511 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150319
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690