Protein Alignment Ugt302K1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_001287281.1
• Gene: Ugt302K1 / 53502
• FlyBaseID: FBgn0040251
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 151/560 - (26%)
• Similarity: 257/560 - (45%)
• Gaps: 87/560 - (15%)

  Fly     6 LILGLLCSLGY----SSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITV----VSVFPQKKP 62
            |..|||..|..    .||  .::|:.:.|....::..|| :.|...||.:.|    |:::.:::.
Human    12 LATGLLLLLSVQPWAESG--KVLVVPTDGSHWLSMREAL-RDLHARGHQVVVLTLEVNMYIKEEN 73

  Fly    63 IPGYTDVSVPNVIEVMGGDIGALWASIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFLKS---- 123
            ....|..::.             |.  |..:.:.|:.|.|..|.....|.:.|.....:.:
Human    74 FFTLTTYAIS-------------WT--QDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLI 123

  Fly   124 ----------NQ---------SFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGS 169
                      |:         |||.::.:.|:..|.. ||::.:.|.:....  .:....|..|:
Human   124 IHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAV-LAKYLSIPAVFFLR--NIPCDLDFKGT 185

  Fly   170 --PAPASFVPHIMLPFNDHMSLYERLLNVAF---LGYERVLLDYYFLPTQEKLYKEFFPGNKRCF 229
              |.|:|::|.::...:|||:..:|:.|:.:   |.|    |.:........|..|.|
Human   186 QCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSY----LCHAVSAPYASLASELF------- 239

  Fly   230 YKMRRNASLVLINQHVS---------LSFPRPHSPNMIEVGGMH-IDGKWNPLPEKIERFINES- 283
               :|..|:|.:..|.|         :.:|||..|||:.:||:: .:||  ||.::.|.:||.|
Human   240 ---QREVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGK--PLSQEFEAYINASG 299

  Fly   284 EHGAIYFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDIL 348
            |||.:.||:||  ...::|..|...|..|||.:.|.|||::......|...|..:..|.||.|:|
Human   300 EHGIVVFSLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL 362

  Fly   349 AHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKA 413
            .||...||:||.|.....|||.:..|::.:|:|.||..|....|..|.|:.|:...:.:.:...|
Human   363 GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENA 427

  Fly   414 IERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDV 478
            ::.:.::.||.:.:..:|..::|:...|::.|::|||.|.||:||.:|:.||..|.|:|||::||
Human   428 LKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV 492

  Fly   479 L-LIIFVVMVLLLIVLPITIYKLLKKLLLKGERTQSTKVK 517
            : .::.||:.:..|......|...|.|..||...::.|.|
Human   493 IGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	141/521 (27%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	143/534 (27%)
		egt	<262..508	CDD:223071	88/249 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150607
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790