DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and UGT1A6

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001063.2	Gene:	UGT1A6 / 54578	HGNCID:	12538	Length:	532	Species:	Homo sapiens

Alignment Length:	529	Identity:	156/529 - (29%)
Similarity:	250/529 - (47%)	Gaps:	61/529 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LMVLNSAGRSHFNVGHALAKGLVKAGHTITVV----------SVFPQKK--PIPGYTDVSVPNVI 75
            |:|:...| ||:.....:.:.|...||.|.||          |.:..:|  |:| |....:.|..
Human    29 LLVVPQDG-SHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVP-YDQEELKNRY 91

  Fly    76 EVMGGDIGA---LWASIQKTYTQNLIDHYQMG--FRITRGLFEDSNFQDFLKSNQSFDAII---- 131
            :..|.:..|   ...:.|..|..|:|   .:|  |...:.|.:|.:..:|.|.:: |||:.
Human    92 QSFGNNHFAERSFLTAPQTEYRNNMI---VIGLYFINCQSLLQDRDTLNFFKESK-FDALFTDPA 152

  Fly   132 --CETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPASFVPHIMLPFNDHMSLYERLL 194
              |...       |||:...|.:.|..|...:.......||.|.|::|.....|:|||:..:|:.
Human   153 LPCGVI-------LAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVA 210

  Fly   195 NVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRNASLVLINQHVS---------LSFP 250
            |  ||  ..:|..|.|.....| |:|....      .::|:..::.:.|.||         |.:|
Human   211 N--FL--VNLLEPYLFYCLFSK-YEELASA------VLKRDVDIITLYQKVSVWLLRYDFVLEYP 264

  Fly   251 RPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDLPPSKVQEILKALG 314
            ||..|||:.:||::.. |...|.::.|.:||.| |||.:.||:||  ...::|..|...|..|||
Human   265 RPVMPNMVFIGGINCK-KRKDLSQEFEAYINASGEHGIVVFSLGS--MVSEIPEKKAMAIADALG 326

  Fly   315 GLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLP 379
            .:.|.|||::......|...|..:..|.||.|:|.||...||:||.|.....|||.:..|::.:|
Human   327 KIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMP 391

  Fly   380 IFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIEN 444
            :|.||..|....|..|.|:.|:...:.:.:...|::.:.::.||.:.:..:|..::|:...|::.
Human   392 LFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDL 456

  Fly   445 AIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMVLLLIVLPITIYKLLKKLLLKG 508
            |::|||.|.||:||.:|:.||..|.|:|||::||: .::.||:.:..|......|...|.|..||
Human   457 AVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKG 521

  Fly   509 ERTQSTKVK 517
            ...::.|.|
Human   522 RVKKAHKSK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	146/490 (30%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	149/503 (30%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	154/520 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150655
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690