DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and UGT1A7

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_061950.2	Gene:	UGT1A7 / 54577	HGNCID:	12539	Length:	530	Species:	Homo sapiens

Alignment Length:	545	Identity:	157/545 - (28%)
Similarity:	257/545 - (47%)	Gaps:	61/545 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTDVS 70
            |.:.||.:.|::.. ..|:|:...| ||:....::.:.|:..||.:.||
Human    12 LYVCLLLTCGFAKA-GKLLVVPMDG-SHWFTMQSVVEKLILRGHEVVVV---------------- 58

  Fly    71 VPNVIEVMGGDIGALWASIQKTYTQNLIDH----------------------------YQMGFRI 107
            :|.|...:|..:.....:...:||....|.                            :.:.|..
Human    59 MPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSN 123

  Fly   108 TRGLFEDSNFQDFLKSNQSFDAIICETFYNDAHYGL--AEHFNAPLIGLATGGGLTFITDMVGSP 170
            .|.||.|....::||.: .|||:..:.|  || .||  |::|:.|.:..|.|....::.:....|
Human   124 CRSLFNDRKLVEYLKES-CFDAVFLDPF--DA-CGLIVAKYFSLPSVVFARGIFCHYLEEGAQCP 184

  Fly   171 APASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRN 235
            ||.|:||.::|.|:|.|:..||:.|......|.:...|:|....| :..|... .....|.:..:
Human   185 APLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLE-IASEILQ-TPVTAYDLYSH 247

  Fly   236 ASLVLINQHVSLSFPRPHSPNMIEVGGMHI-DGKWNPLPEKIERFINES-EHGAIYFSMGSNLKT 298
            .|:.|:.....|.:|:|..||||.:||::. .||  |:|.:.|.:||.| |||.:.||:||  ..
Human   248 TSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGK--PVPMEFEAYINASGEHGIVVFSLGS--MV 308

  Fly   299 KDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGML 363
            .::|..|...|..|||.:.|.|||::......|...|..:..|.||.|:|.||...||:||.|..
Human   309 SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSH 373

  Fly   364 STTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQ 428
            ...|||.:..|::.:|:|.||..|....|..|.|:.|:...:.:.:...|::.:.::.||.:.:.
Human   374 GVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIM 438

  Fly   429 GISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMVLLLIV 492
            .:|..::|:...|::.|::|||.|.||:||.:|:.||..|.|:|||::||: .::.||:.:..|.
Human   439 RLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT 503

  Fly   493 LPITIYKLLKKLLLKGERTQSTKVK 517
            .....|...|.|..||...::.|.|
Human   504 FKCCAYGYRKCLGKKGRVKKAHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	147/506 (29%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	151/521 (29%)
UGT1A7	NP_061950.2	egt	<264..504	CDD:223071	87/243 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150381
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690