DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and UGT1A10

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_061948.1	Gene:	UGT1A10 / 54575	HGNCID:	12531	Length:	530	Species:	Homo sapiens

Alignment Length:	543	Identity:	155/543 - (28%)
Similarity:	255/543 - (46%)	Gaps:	57/543 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTDVS 70
            |.:.||.:.|::.. ..|:|:...| ||:....::.:.|:..||.:.||
Human    12 LCVCLLLTCGFAEA-GKLLVVPMDG-SHWFTMQSVVEKLILRGHEVVVV---------------- 58

  Fly    71 VPNVIEVMGGDIGALWASIQKTYT---QN----LIDHYQ---------------------MGFRI 107
            :|.|...:...:.....:...:||   ||    :..|.|                     :.|..
Human    59 MPEVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSH 123

  Fly   108 TRGLFEDSNFQDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAP 172
            .|.||.|....::||.: ||||:..:.| :.....:|::|:.|.:....|.....:.:....|||
Human   124 CRSLFNDRKLVEYLKES-SFDAVFLDPF-DTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAP 186

  Fly   173 ASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRNAS 237
            .|:||:.:|.|:|.|:..||:.|......:.:...|.|....| :..|... .....|.:..:.|
Human   187 LSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALE-IASEILQ-TPVTAYDLYSHTS 249

  Fly   238 LVLINQHVSLSFPRPHSPNMIEVGGMHI-DGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKD 300
            :.|:.....|.:|:|..||||.:||::. .||  |||.:.|.:||.| |||.:.||:||  ...:
Human   250 IWLLRTDFVLDYPKPVMPNMIFIGGINCHQGK--PLPMEFEAYINASGEHGIVVFSLGS--MVSE 310

  Fly   301 LPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLST 365
            :|..|...|..|||.:.|.|||::......|...|..:..|.||.|:|.||...||:||.|....
Human   311 IPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGV 375

  Fly   366 TESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGI 430
            .|||.:..|::.:|:|.||..|....|..|.|:.|:...:.:.:...|::.:.::.||.:.:..:
Human   376 YESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRL 440

  Fly   431 SFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMVLLLIVLP 494
            |..::|:...|::.|::|||.|.||:||.:|:.||..|.|:|||::||: .::.||:.:..|...
Human   441 SSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFK 505

  Fly   495 ITIYKLLKKLLLKGERTQSTKVK 517
            ...|...|.|..||...::.|.|
Human   506 CCAYGYRKCLGKKGRVKKAHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	145/504 (29%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	149/519 (29%)
UGT1A10	NP_061948.1	egt	<258..504	CDD:223071	90/249 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150380
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690