DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt37B1

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	166/538 - (30%)
Similarity:	270/538 - (50%)	Gaps:	42/538 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTDVS 70
            |.|.::..:..:.|.|.|.:..|...||..:..::|:.|.:.||.:|||::.   ||...:.|::
  Fly     8 LALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTIL---KPPSLHKDIN 69

  Fly    71 ---VP---NVIEVMGGDIGALWASIQKTYTQNLIDHYQMGFRITRGLFED-SNFQDFLKS----- 123
               ||   ::::.....:|.:      |.|.|...:..| ||..|.|.|. |...|.:|.
  Fly    70 HILVPMEEDILQAFNSVVGGM------TKTDNSNAYVSM-FRSVRQLSETFSKMGDVMKQPLVKD 127

  Fly   124 -----NQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPASFVP--HIML 181
                 :..||.::...|.|.....||.....||: :|.....:|:..::|:|...|:||  .:.:
  Fly   128 LYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLV-VALSNPPSFLGYLLGNPWEVSYVPGMSVSI 191

  Fly   182 PFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQE-KLYKEFFPGNKR--CFYKMRRNASLVLINQ 243
            .....:....|:||:  ||.....|..:.:..:. ::|:|.:..:..  .:..:.:|.||:....
  Fly   192 KGGKPLGFGHRVLNL--LGSMAQRLFMFIIELRNARIYREIYGDDPTLPSYEDLHKNISLIFFAS 254

  Fly   244 H-VSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINESEHGAIYFSMGSNLKTKDLPPSKVQ 307
            | :|....||:.|.:||:||:.:..:...||:.:|:|::|:.:|||..|:|||||...|..|.||
  Fly   255 HGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFLSEAPNGAILLSLGSNLKEDHLKSSTVQ 319

  Fly   308 EILKALGGLKQRVLWKF-ELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYH 371
            ::...|..|:|:|:||: :|||:|.:.||:..|.|.||.|:||||.|..|:||.|....||:.||
  Fly   320 KMFNVLSKLQQKVIWKWDDLDNIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQYH 384

  Fly   372 AKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRD 436
            .||::.||:|.||..|......:|:||.....||....|.:.|..:...|.|...|:..|..|||
  Fly   385 GKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLYRD 449

  Fly   437 QQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLPITIYKLL 501
            :..:|.|..|||||:|.|:.||.:::|....:::...:|:||..:|...:|.|..     |.|||
  Fly   450 RPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCF-----ITKLL 509

  Fly   502 KKLLLKGERTQSTKVKRN 519
            ..|::...|..|.|.|.|
  Fly   510 FGLVVGKLRKNSRKAKVN 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	153/497 (31%)
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	161/528 (30%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	148/482 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445799
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950